dc.contributor.author |
Yılmaz, Mehmet |
|
dc.date.accessioned |
2019-07-12T12:21:37Z |
|
dc.date.available |
2019-07-12T12:21:37Z |
|
dc.date.issued |
2018 |
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dc.identifier.citation |
Yılmaz, M. (2018). Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy. Cilt:33 Sayı:2, 110-116 ss. |
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dc.identifier.uri |
http://hdl.handle.net/11616/12579 |
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dc.description.abstract |
Purpose: To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver.
Methods: Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathological specimens were studied using the Ki-67 Proliferation Index(PI); and arginase(Arg), tissue plasminogen activator(tPA), ceruloplasmin(Cer) and nitric oxide(NO) were studied in biochemical analysis.
Results: Our results showed that Ki-67 proliferation index was low in Groups 1. The proliferation coefficient was significantly higher in the Group 2 and Group 4 than in the Group 1 and Group 3.(P < 0.001 between Groups 1 and 2, 1 and 4, and 3 and 4). There was no difference between Groups 2 and 4 (P = 1). The results of the biochemical Arg, tPA and Cer test showed statistically between the Group 1 and Group 2. NO showed significant differences Group 1 and 3.
Conclusions: Thymoquinone and curcumin both have known positive effects on the organism. Histological and biochemical tests showed that thymoquinone is more effective than curcumin. |
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dc.language.iso |
eng |
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dc.publisher |
ACTA CIRURGICA BRASILEIRA, ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL |
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dc.relation.isversionof |
10.1590/s0102-865020180020000002 |
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dc.rights |
info:eu-repo/semantics/openAccess |
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dc.subject |
Nıgella-Satıva |
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dc.subject |
Hepatocellular-Carcınoma |
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dc.subject |
Remnant |
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dc.subject |
Prolıferatıon |
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dc.subject |
Toxıcıty |
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dc.subject |
Volume |
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dc.subject |
Mıce |
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dc.subject |
Oıl |
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dc.title |
Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy |
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dc.type |
article |
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dc.relation.ispartof |
Acta cırurgıca brasıleıra |
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dc.department |
İnönü Üniversitesi |
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dc.identifier.volume |
33 |
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dc.identifier.issue |
2 |
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dc.identifier.startpage |
110 |
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dc.identifier.endpage |
116 |
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