dc.contributor.author |
Eşrefoğlu, Mukaddes |
|
dc.contributor.author |
Akıncı, Ayşin |
|
dc.contributor.author |
Elbe, Hülya |
|
dc.contributor.author |
Taşlıdere, Elif |
|
dc.contributor.author |
Taşlıdere, Elif |
|
dc.contributor.author |
Çetin, Aslı |
|
dc.contributor.author |
Ateş, Burhan |
|
dc.date.accessioned |
2020-10-21T11:47:57Z |
|
dc.date.available |
2020-10-21T11:47:57Z |
|
dc.date.issued |
2014 |
|
dc.identifier.citation |
EŞREFOĞLU M,AKINCI A,ELBE H,TAŞLIDERE E,ÇETİN A,ATEŞ B (2014). Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. Turkish Journal of Biology, 38(4), 493 - 501. |
en_US |
dc.identifier.uri |
https://app.trdizin.gov.tr/makale/TVRZek1EUTVPUT09 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/18454 |
|
dc.description.abstract |
Abstract:In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even higher than those of control group in all of the organs. As a conclusion, we found melatonin very effective in reducing stress-induced organ damage by inhibiting lipid peroxidation and supporting the cellular antioxidant defense system. |
en_US |
dc.language.iso |
tur |
en_US |
dc.publisher |
Turkish Journal of Biology |
en_US |
dc.rights |
info:eu-repo/semantics/openAccess |
en_US |
dc.title |
Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats |
en_US |
dc.type |
article |
en_US |
dc.relation.ispartof |
Turkish Journal of Biology |
en_US |
dc.department |
İnönü Üniversitesi |
en_US |