Investigation of antidepressant -like effect of pari-flo product on forced swimming test in balb-c mice

Abstract

Abstract:Pari-flo is a commercial preparation in the form of a solution containing standardized Passiflora incarnata plant extract. We hypothesized that Pari-flo may have antidepressant potential with its content. Therefore, the aim of this study was investigation of the antidepressant-like effect of Pari-flo product comparing with imipramine based on Forced Swimming Test (FST) in Balb-c Mice. Forty-two male Balb-c mice were divided into 6 equal groups as follows: group 1 (control) were fed with normal rat chow and tap water, groups (2, 3, 4 and 5) were given 125, 250, 500 and 1000 mg/kg/day dose Pari-flo respectively, group (6) were given 15 mg/kg/day dose imipramine. After 7 days of treatment, the FST was carried out. Pari-flo significantly reduced the immmobility time while increased the climbing time in FST at the dose of 500 and 1000 mg/kg/day. At the 1000 mg/kg/day dose of Pari-flo was increased the swimming time in FST. Imipramine was also increased the swimming and climbing time, while reduced the immobility time. Based on FST test results, it is concluded that Pari-flo product has antidepressant-like activity comparable to those of imipramine in experimental animal models.