YOĞUN BAKIM ÜNİTELERİNDEN İZOLE EDİLEN PSEUDOMONAS AERUGİNOSA SUŞLARININ ANTİBİYOTİKLERE DUYARLILIKLARI

Abstract

Öz:Pseudomonas aeruginosastrains are frequently isolated, especially from inpatient samples in intensive care units. These strains lead to infections that are difficult to treat due to antibiotic resistance, thus increasing morbidity and mortality. The aim of this study is to determine the resistance of P. aeruginosaisolates, isolated from intensive care patients of Malatya Training and Research Hospital, to various antibiotics. P. aeruginosastrains isolated from various clinical samples of patients who were followed up in intensive care units of Malatya Training and Research Hospital between July 2016 and July 2019, were included in the study. Identification and in vitro antibiotic susceptibility of the strains were determined using Vitek 2 automated system (bioMérieux, France). Of the 468 P. aeruginosastrains included in the study, 51.7% were isolated from respiratory tract samples, followed by urine samples with 31.2% and, abscess and wound samples with 9%. Colistin and norfloxacin were determined to be the most effective antibiotics for P. aeruginosastrains, while the lowest susceptibility was determined for aztreonam among the studied antibiotics. Susceptibility rates were determined to be; 76.5% for amikacin, 8.1% for aztreonam, 74.4% for gentamicin, 62.2% for imipenem, 97.1% for colistin, 57.5% for levofloxacin, 61.4% for meropenem, 57.4% for netilmisin, 89.9% for norfloxacin, 48.7% for piperacillin/tazobactam, 35.7% for piperacillin, 57.7% for cefepime, 62.7% for ceftazidime, 66% for ciprofloxacin, and 80.9% for tobramycin. In order to develop effective and accurate infection control strategies and reduce morbidity and mortality, it is important to know the distribution and susceptibility of infectious agents, especially in critical patients in intensive care units.