dc.contributor.author |
Topal, Erdem |
|
dc.contributor.author |
Sayan, Yekbun Gamze |
|
dc.date.accessioned |
2022-02-22T11:32:36Z |
|
dc.date.available |
2022-02-22T11:32:36Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Gamze Sayan, Y., & Topal, E. (2021). The historical factors associated with the true non-steroidal anti-inflammatory drug hypersensitivity in children . Annals of Medical Research |
en_US |
dc.identifier.uri |
http://hdl.handle.net/11616/53804 |
|
dc.description.abstract |
Aim: To determine the frequency of true NSAIDs hypersensitivity in children and whether there were any parameters in the history to
predict NSAIDs hypersensitivity.
Material and Methods: Children who applied to outpatient clinic with a history suggesting NSAID hypersensitivity were evaluated by
a pediatric allergist. The confirmed NSAID hypersensitivity was found by skin test and/or oral provocation tests.
Results: Fifty patients who were admitted with a suspicion of immediate-type reaction to NSAID were included in the study. The
median age of the patients was 6 (1-16) years old and 28 (56%) of the patients were male. We performed skin tests with the suspected
NSAID in 28 (56%) patients. Of these, 2 had positive results. Provocation tests were performed on 48 patients whose skin tests were
negative or skin tests were not available. During the provocation tests, 11 patients (22%) developed reaction. Clinical parameters in
history were evaluated by using univariate analysis; the age of child ≥ 6 years old (p=0.006), family history of NSAIDs hypersensitivity
(p=0.039), presence of multiple immediate type NSAIDs hypersensitivity in history (p=0.01), emergence of reaction within an hour
(p=0.004) were found as significant factors to predicted true NSAID hypersensitivity in history.
Conclusions: The diagnosis of immediate type NSAIDs hypersensitivity was not done by clinical history, oral provocation tests
should be done for true diagnosis. However, the age of child ≥ 6 years old, family history of NSAIDs hypersensitivity, presence of
multiple immediate type NSAIDs hypersensitivity in history, emergence of reaction within an hour in history can predict the true
NSAIDs hypersensitivity |
en_US |
dc.language.iso |
eng |
en_US |
dc.rights |
info:eu-repo/semantics/openAccess |
en_US |
dc.title |
The historical factors associated with the true non-steroidal anti-inflammatory drug hypersensitivity in children |
en_US |
dc.type |
article |
en_US |
dc.relation.journal |
Annals of Medical Research |
en_US |
dc.contributor.department |
İnönü Üniversitesi |
en_US |