Elevated serum uric acid levels are associated with increased risk score and MACE development in patients with STEMI

Abstract

Aim: Although the relationship between changes in serum uric acid (UA) levels and adverse events in ST segment elevation myocardial infarction (STEMI) patients is well known, the effect of an increase in UA levels on risk scores or major adverse cardiovascular event (MACE) development are not well established. In this study, we investigated the effects of ordinal changes in serum UA levels on adverse events and risk scores in STEMI patients. Material and Methods: The patients presenting with a diagnosis of STEMI and undergoing coronary angiography were included in the study. The patients were divided into seven groups evenly according to baseline UA levels and the effects of changes in UA levels on risk score and MACE were investigated. Results: A total 1200 STEMI patients was included in the study. The mean age of the patients was 62 years and 72% of them were males. While both Syntax score-II (SS-2) and Cadillac scores (CS) were lower among Group-1 and Group-4; SS-2, CS and development of MACE were markedly increased with an increase in UA levels. Conclusions: The UA levels in STEMI patients can be guiding for the clinician regarding the development of adverse event and patient-based intensive approaches should be considered in the patients with higher UA levels.