The investigation of guillain-barre syndrome and prognosis

Abstract

Aim: Guillain-Barre Syndrome (GBS) is an immune-mediated disease of peripheral nervous system. It is important to estimate the prognosis because of disability burden and morbidity. In addition to clinical features and disease severity scales, serum biomarkers were used to estimate prognosis. We aimed to determine the subtypes, demographic and clinical characteristics of GBS patients, and the factors affecting the short-term prognosis. Material and Methods: The medical files of 94 patients who were followed up with diagnosis of GBS between January 2011 and January 2018 were retrospectively reviewed. Demographic and clinical features, disease severity scores, and neutrophil/lymphocyte (N/L) ratios were determined, and the effects of these parameters on short-term prognosis were investigated. Results: Most of the patients (60.6%) had acute inflammatory demyelinating polyneuropathy (AIDP) subtype. A majority of the cases were men and were in 5 to 7th decades of age. There was no seasonal relevance with the disease. 77% of the cases had albuminocytologic dissociation. The short-term prognosis was associated with age, respiratory failure, cranial nerve involvement and N/L ratio. Conclusion: It is important to estimate the prognosis in GBS. In our study, age, respiratory failure, cranial nerve involvement and N/L ratio were found as related factors with short-term prognosis.