dc.contributor.author |
Kaya, Yasin Emre |
|
dc.contributor.author |
Karaarslan, Numan |
|
dc.contributor.author |
Yilmaz, İbrahim |
|
dc.contributor.author |
Yasar Sirin, Duygu |
|
dc.contributor.author |
Yaman, Onur |
|
dc.contributor.author |
Ozbek, Hanefi |
|
dc.contributor.author |
Ates, Ozkan |
|
dc.date.accessioned |
2022-03-09T09:44:35Z |
|
dc.date.available |
2022-03-09T09:44:35Z |
|
dc.date.issued |
2020 |
|
dc.identifier.citation |
Emre Kaya, Y., Karaarslan, N., Yilmaz, I., Yasar Sirin, D., Yaman, O., Ozbek, H., & Ates, O. (2021). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures . Annals of Medical Research |
en_US |
dc.identifier.uri |
http://hdl.handle.net/11616/54932 |
|
dc.description.abstract |
Aim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P 0.05). Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment. |
en_US |
dc.language.iso |
eng |
en_US |
dc.rights |
info:eu-repo/semantics/openAccess |
en_US |
dc.title |
Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures |
en_US |
dc.type |
article |
en_US |
dc.relation.ispartof |
Annals of Medical Research |
en_US |
dc.department |
İnönü Üniversitesi |
en_US |