Coexistence of pituitary incidentaloma and primary hyperparathyroidism mimicking multiple endocrine neoplasia Type 1: A case report

Abstract

The widespread use of imaging procedures has led to an increased discovery of incidental masses in the pituitary gland. Although the majority of pituitary incidentalomas are non-functioning benign adenomas but their increased prevalence poses a diagnostic and therapeutic challenge. These masses may cause various hormonal disturbances as well as they might also be a component of multiple endocrine neoplasia syndromes type 1 (MEN-1) or type 4 (MEN-4). In both syndromes, primary hyperparathyroidism frequently accompanies with pituitary adenomas. Herein we present a 56-year-old man with pituitary incidentaloma who is also detected primary hyperparathyroidism. Contrary to our expectations, any gene defects could be found related with neither MEN-1 nor MEN-4 in the genetic examination.