dc.contributor.author |
Alpaslan Duman, Aslihan |
|
dc.contributor.author |
Ates Ozdemir, Deniz |
|
dc.contributor.author |
Tuncel, Ferah |
|
dc.contributor.author |
Usubutun, Alp |
|
dc.contributor.author |
Usubutun, Alp |
|
dc.date.accessioned |
2022-03-21T14:00:38Z |
|
dc.date.available |
2022-03-21T14:00:38Z |
|
dc.date.issued |
2022 |
|
dc.identifier.citation |
Duman, A. A., Ozdemir, D. A., Tuncel, F., Usubutun, A., & Usubutun, A. (2022). Novel immunohistochemical marker in the differential diagnosis of sex cord-stromal tumors: SF-1. Annals of Medical Research, |
en_US |
dc.identifier.uri |
http://hdl.handle.net/11616/56715 |
|
dc.description.abstract |
Aim: Sex cord-stromal tumors are relatively uncommon tumors which constitute approximately 8% of all primary ovarian neoplasms. Morphologic differentiation of non-SCST from SCSTs can be challenging due to microscopic overlap. Immunohistochemistry is beneficial in challenging cases. Inhibin and calretinin have limited sensitivity and specificity, a more sensitive marker is required. SF-1 is known as a promising immunohistochemical marker in the differentiation of SCST from non-SCST ovarian tumors. For this purpose, various non-SCSTs (metastatic and non-metastatic) having morphologic overlap with SCSTs, and multiple SCSTs were stained with SF-1 antibody to elucidate its importance in morphologically challenging cases.
Materials and Methods: Twenty-three SCST, 40 non-SCSTs, and an ectopic adrenal tissue were stained with SF-1, and also the percentage and the intensity were scored. SF-1 immunoreactivity was seen in all 23 SCST with varying degrees of intensity and percentage. In contrast, non-SCSTs were negative in all regarding to SF-1. Ectopic adrenal gland tissue and ovarian stroma are positive as non-tumoral lesions.
Results: In our series, SF-1 immunoreactivity was seen in all 23 SCST and ectopic adrenal tissue with varying degrees of intensity and diffuseness. In contrast, non-SCSTs were all negative concerning SF-1. In addition; we observed nuclear positivity with SF-1 in 15-75% of the sclerosing stromal tumor cells, whereas inhibin and calretinin were negative in all 4 cases.
Conclusion: Our data shows that SF-1 is a nuclear, reliable and surrogate marker for all SCSTs, and can be used routinely. |
en_US |
dc.language.iso |
eng |
en_US |
dc.rights |
info:eu-repo/semantics/openAccess |
en_US |
dc.title |
Novel immunohistochemical marker in the differential diagnosis of sex cord-stromal tumors: SF-1 |
en_US |
dc.type |
article |
en_US |
dc.relation.journal |
Annals of Medical Research |
en_US |
dc.contributor.department |
İnönü Üniversitesi |
en_US |