| dc.contributor.author |
Erdemli, ME |
|
| dc.contributor.author |
Aladag, MA |
|
| dc.contributor.author |
Altinoz, E |
|
| dc.contributor.author |
Demirtas, S |
|
| dc.contributor.author |
Turkoz, Y |
|
| dc.contributor.author |
Yigitcan, B |
|
| dc.contributor.author |
Bag, HG |
|
| dc.date.accessioned |
2022-08-08T08:35:41Z |
|
| dc.date.available |
2022-08-08T08:35:41Z |
|
| dc.date.issued |
2018 |
|
| dc.identifier.uri |
http://hdl.handle.net/11616/60136 |
|
| dc.description.abstract |
Objectives: The aim of this study is to elucidate the possible mechanism of neurotoxic effect of acrylamide (AA) applied during pregnancy on fetal brain development and to show the effect of N-acetylcysteine (NAC) on AA toxicity. |
|
| dc.description.abstract |
Materials and methods: Four groups were formed with 9 pregnant rats each as control (C), acrylamide (AA), N-acetylcysteine (NAC), acrylamide plus N-acetylcysteine (AA plus NAC) groups. Caesarian section was implemented on the 20th day of pregnancy. Malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and Brain-derived neurotrophic factor (BDNF) levels were analyzed and histopathologic examinations were performed in brain tissues of the fetuses. |
|
| dc.description.abstract |
Results: Our data indicated that AA caused necrotic death and hemorrhagic damages in fetal brain tissue with decreasing BNDF levels and increasing oxidative stress. N-acetylcysteine prevented the toxic effects of its on fetal brain (p < 0.05). |
|
| dc.description.abstract |
Conclusion: Our study indicated that acrylamide has toxic effects in the fetal brain and N-acetylcysteine prevents its toxic effect. |
|
| dc.description.abstract |
C1 [Erdemli, Mehmet Erman] Omer Halisdemir Univ, Fac Med, Dept Med Biochem, Nigde, Turkey. |
|
| dc.description.abstract |
[Aladag, M. Arif] Inonu Univ, Dept Neurosurg, Fac Med, Malatya, Turkey. |
|
| dc.description.abstract |
[Altinoz, Eyup] Karabuk Univ, Fac Med, Dept Med Biochem, Karabuk, Turkey. |
|
| dc.description.abstract |
[Demirtas, Sezin; Turkoz, Yusuf] Inonu Univ, Fac Med, Dept Med Biochem, Malatya, Turkey. |
|
| dc.description.abstract |
[Yigitcan, Birgul] Inonu Univ, Fac Med, Dept Histol & Embryol, Malatya, Turkey. |
|
| dc.description.abstract |
[Bag, Harika Gozukara] Inonu Univ, Fac Med, Dept Biostat, Malatya, Turkey. |
|
| dc.source |
NEUROTOXICOLOGY AND TERATOLOGY |
|
| dc.title |
Acrylamide applied during pregnancy causes the neurotoxic effect by |
|
| dc.title |
lowering BDNF levels in the fetal brain |
|