dc.contributor.author |
Atay, FF |
|
dc.contributor.author |
Taskapan, H |
|
dc.contributor.author |
Berktas, B |
|
dc.contributor.author |
Yildirim, O |
|
dc.contributor.author |
Dogan, M |
|
dc.contributor.author |
Piskin, T |
|
dc.date.accessioned |
2022-08-12T06:41:18Z |
|
dc.date.available |
2022-08-12T06:41:18Z |
|
dc.date.issued |
2019 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/60657 |
|
dc.description.abstract |
Purpose. In healthy individuals, glomerular filtration rate decreases by 1 mL/min/y after a peak level of 125.0 mL/min has been reached in adulthood. Any reduction greater than this is a progressive slope (slope more negative than 1 mL/min/y, stable [-1 to +1]), or an improvable slope if it shows more of an increase, that is, greater than +1.0 mL/min/y). The aim of the study was to determine the factors affecting estimated glomerular filtration rate (eGFR) slope during the first 2 years of renal transplant in patients with negative pretransplant panel-reactive antibody. |
|
dc.description.abstract |
Materials and Methods. The characteristics of 59 renal transplant patients, such as age, sex, etiology, and 2 years of laboratory data, were collected retrospectively. For each patient, the eGFR decline rate (slope) (mL/min-1/1.73 m(2)-1/y-1) was determined by linear regression analysis using all calculated eGFR values over the study period. |
|
dc.description.abstract |
Findings. Of 59 patients, 7 (11.8%) had a progressive slope, 22 (37.2%) had a stable slope, and 30 (50.8%) had an improvable slope. The first-year mean tacrolimus level was lower in patients with progressive slope than in the patients with stable slope and improvable slope (P < .022). The determinants of eGFR slope in multiple regression analysis were post-transplant hypertension (beta = 0.393; P = .002) and the first-year mean tacrolimus level (beta = 0.320; P =.01), whereas age, serum albumin, and 2-year mean tacrolimus level did not reach the level of significance. |
|
dc.description.abstract |
Conclusion. Keeping tacrolimus levels high in the first year to prevent eGFR declining is important. |
|
dc.description.abstract |
C1 [Atay, Feyza Firat; Berktas, Bayram] Inonu Univ, Nephrol, Malatya, Turkey. |
|
dc.description.abstract |
[Taskapan, Hulya; Yildirim, Okan] Inonu Univ, Radiol, Malatya, Turkey. |
|
dc.description.abstract |
[Dogan, Murat; Piskin, Turgut] Inonu Univ, Gen Surg, Malatya, Turkey. |
|
dc.source |
TRANSPLANTATION PROCEEDINGS |
|
dc.title |
Factors Affecting eGFR Slope of Renal Transplant Patients During the |
|
dc.title |
First 2 Years |
|