dc.contributor.author |
Azukaitis, K |
|
dc.contributor.author |
Ju, WJ |
|
dc.contributor.author |
Kirchner, M |
|
dc.contributor.author |
Nair, V |
|
dc.contributor.author |
Smith, M |
|
dc.contributor.author |
Fang, ZY |
|
dc.contributor.author |
Thurn-Valsassina, D |
|
dc.contributor.author |
Bayazit, A |
|
dc.contributor.author |
Niemirska, A |
|
dc.contributor.author |
Canpolat, N |
|
dc.contributor.author |
Bulut, IK |
|
dc.contributor.author |
Yalcinkaya, F |
|
dc.contributor.author |
Paripovic, D |
|
dc.contributor.author |
Harambat, J |
|
dc.contributor.author |
Cakar, N |
|
dc.contributor.author |
Alpay, H |
|
dc.contributor.author |
Lugani, F |
|
dc.contributor.author |
Mencarelli, F |
|
dc.contributor.author |
Civilibal, M |
|
dc.contributor.author |
Erdogan, H |
|
dc.contributor.author |
Gellermann, J |
|
dc.contributor.author |
Vidal, E |
|
dc.contributor.author |
Tabel, Y |
|
dc.contributor.author |
Gimpel, C |
|
dc.contributor.author |
Ertan, P |
|
dc.contributor.author |
Yavascan, O |
|
dc.contributor.author |
Melk, A |
|
dc.contributor.author |
Querfeld, U |
|
dc.contributor.author |
Wuhl, E |
|
dc.contributor.author |
Kretzler, M |
|
dc.contributor.author |
Schaefer, F |
|
dc.contributor.author |
Arbeiter, K |
|
dc.contributor.author |
Rosales, A |
|
dc.contributor.author |
Dusek, J |
|
dc.contributor.author |
Zaloszyc, A |
|
dc.contributor.author |
Liebau, M |
|
dc.contributor.author |
Weber, L |
|
dc.contributor.author |
Muschiol, E |
|
dc.contributor.author |
Buscher, R |
|
dc.contributor.author |
Oh, J |
|
dc.contributor.author |
Thurn-Valassina, D |
|
dc.contributor.author |
Haffner, D |
|
dc.contributor.author |
John, U |
|
dc.contributor.author |
Wygoda, S |
|
dc.contributor.author |
Jeck, N |
|
dc.contributor.author |
Wigger, M |
|
dc.contributor.author |
Testa, S |
|
dc.contributor.author |
Murer, L |
|
dc.contributor.author |
Matteucci, C |
|
dc.contributor.author |
Jankauskiene, A |
|
dc.contributor.author |
Drozdz, D |
|
dc.contributor.author |
Zurowska, A |
|
dc.contributor.author |
Zaniew, M |
|
dc.contributor.author |
Litwin, M |
|
dc.contributor.author |
Nimierska, A |
|
dc.contributor.author |
Teixeira, A |
|
dc.contributor.author |
Peco-Antic, A |
|
dc.contributor.author |
Laube, G |
|
dc.contributor.author |
Dali, CNB |
|
dc.contributor.author |
Anarat, A |
|
dc.contributor.author |
Duzova, A |
|
dc.contributor.author |
Bilginer, Y |
|
dc.contributor.author |
Caliskan, S |
|
dc.contributor.author |
Mir, S |
|
dc.contributor.author |
Sozeri, B |
|
dc.contributor.author |
Kranz, B |
|
dc.contributor.author |
Dorn, B |
|
dc.contributor.author |
Baskin, E |
|
dc.contributor.author |
Soylemezoglu, O |
|
dc.contributor.author |
Emre, S |
|
dc.contributor.author |
Candan, C |
|
dc.contributor.author |
Kiyak, A |
|
dc.contributor.author |
Ozcelik, G |
|
dc.contributor.author |
Shroff, R |
|
dc.contributor.author |
Rachin, B |
|
dc.contributor.author |
Szczepanska, M |
|
dc.contributor.author |
Donmez, O |
|
dc.contributor.author |
Balat, A |
|
dc.contributor.author |
Aksu, N |
|
dc.contributor.author |
Yilmaz, E |
|
dc.contributor.author |
Bakkaloglu, A |
|
dc.contributor.author |
Ozaltin, F |
|
dc.contributor.author |
Sallay, P |
|
dc.contributor.author |
Bonzel, KE |
|
dc.contributor.author |
Wingen, AM |
|
dc.contributor.author |
Urowska, AZ |
|
dc.contributor.author |
Balasz, I |
|
dc.contributor.author |
Trivelli, A |
|
dc.contributor.author |
Perfumo, F |
|
dc.contributor.author |
Muller-Wiefel, DE |
|
dc.contributor.author |
Moller, K |
|
dc.contributor.author |
Offner, G |
|
dc.contributor.author |
Enke, B |
|
dc.contributor.author |
Hadtstein, C |
|
dc.contributor.author |
Mehls, O |
|
dc.contributor.author |
Hohbach-Hohenfellner, K |
|
dc.contributor.author |
Klaus, G |
|
dc.contributor.author |
Ardissino, G |
|
dc.contributor.author |
Montini, G |
|
dc.contributor.author |
Charbit, M |
|
dc.contributor.author |
Niaudet, P |
|
dc.contributor.author |
Afonso, AC |
|
dc.contributor.author |
Fernandes-Teixeira, A |
|
dc.contributor.author |
Picca, S |
|
dc.contributor.author |
Berg, UB |
|
dc.contributor.author |
Celsi, G |
|
dc.contributor.author |
Fischbach, M |
|
dc.contributor.author |
Terzic, J |
|
dc.contributor.author |
Fydryk, J |
|
dc.contributor.author |
Urasinski, T |
|
dc.contributor.author |
Coppo, R |
|
dc.contributor.author |
Peruzzi, L |
|
dc.contributor.author |
Grenda, R |
|
dc.contributor.author |
Neuhaus, TJ |
|
dc.date.accessioned |
2022-09-22T08:28:09Z |
|
dc.date.available |
2022-09-22T08:28:09Z |
|
dc.date.issued |
2019 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/61692 |
|
dc.description.abstract |
Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6-17 years with baseline estimated glomerular filtration rate (eGFR) of 10-60 ml/min/1.73 m(2). uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for <10% of cases. Median eGFR at baseline was 28 ml/min/1.73 m(2), and 288 of 623 participants (46.3%) reached the composite endpoint of CKD progression (50% eGFR loss, eGFR < 10 ml/min/1.73 m(2), or initiation of renal replacement therapy). In a Cox proportional hazards model, higher uEGF/Cr was associated with a decreased risk of CKD progression (HR 0.76; 95% CI 0.69-0.84) independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure. The addition of uEGF/Cr to a model containing these variables resulted in a significant improvement in C-statistics, indicating better prediction of the 1-, 2- and 3-year risk of CKD progression. External validation in a prospective cohort of 222 children with CKD demonstrated comparable results. Thus, uEGF may be a useful biomarker to predict CKD progression in children with CKD. |
|
dc.description.abstract |
C1 [Azukaitis, Karolis] Vilnius Univ, Inst Clin Med, Clin Pediat, Fac Med, Vilnius, Lithuania. |
|
dc.description.abstract |
[Ju, Wenjun; Nair, Viji; Smith, Michelle; Fang, Zhiyin; Kretzler, Matthias; 4C Study & ESCAPE Trial Grp] Univ Michigan, Dept Internal Med Nephrol, Ann Arbor, MI 48109 USA. |
|
dc.description.abstract |
[Ju, Wenjun; Kretzler, Matthias] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA. |
|
dc.description.abstract |
[Kirchner, Marietta] Heidelberg Univ, Inst Med Biometry & Informat, Heidelberg, Germany. |
|
dc.description.abstract |
[Thurn-Valsassina, Daniela; Melk, Anette] Hannover Med Sch, Dept Kidney Liver & Metab Dis, Hannover, Germany. |
|
dc.description.abstract |
[Bayazit, Aysun] Cukurova Univ, Dept Pediat Nephrol, Adana, Turkey. |
|
dc.description.abstract |
[Niemirska, Anna] Childrens Mem Hlth Inst, Dept Nephrol Kidney Transplantat & Arterial Hyper, Warsaw, Poland. |
|
dc.description.abstract |
[Canpolat, Nur] Istanbul Univ, Dept Pediat Nephrol, Cerrahpasa Fac Med, Istanbul, Turkey. |
|
dc.description.abstract |
[Bulut, Ipek Kaplan] Ege Univ, Div Pediat Nephrol, Dept Pediat, Fac Med, Izmir, Turkey. |
|
dc.description.abstract |
[Yalcinkaya, Fatos; Cakar, Nilgun] Ankara Univ, Sch Med, Dept Pediat, Div Pediat Nephrol, Ankara, Turkey. |
|
dc.description.abstract |
[Paripovic, Dusan] Univ Childrens Hosp, Dept Pediat Nephrol, Belgrade, Serbia. |
|
dc.description.abstract |
[Harambat, Jerome] Bordeaux Univ Hosp, Dept Pediat, Bordeaux, France. |
|
dc.description.abstract |
[Alpay, Harika] Marmara Univ, Dept Pediat Nephrol, Fac Med, Istanbul, Turkey. |
|
dc.description.abstract |
[Lugani, Francesca] Univ Genoa, G Gaslini Inst, Div Nephrol, Dialysis, Genoa, Italy. |
|
dc.description.abstract |
[Mencarelli, Francesca] Univ Bologna, S Orsola Malpighi Hosp, Dept Pediat, Pediat Nephrol Unit, Bologna, Italy. |
|
dc.description.abstract |
[Civilibal, Mahmut] Haseki Educ & Res Hosp, Dept Pediat Nephrol, Istanbul, Turkey. |
|
dc.description.abstract |
[Erdogan, Hakan] Bursa Yuksek Ihtisas Teaching & Researching Hosp, Dept Pediat Nephrol, Bursa, Turkey. |
|
dc.description.abstract |
[Gellermann, Jutta] Charite Childrens Hosp, Pediat Nephrol, Berlin, Germany. |
|
dc.description.abstract |
[Vidal, Enrico] Univ Hosp Padova, Dept Womans & Childs Hlth, Pediat Nephrol Dialysis & Transplantat Unit, Padua, Italy. |
|
dc.description.abstract |
[Tabel, Yilmaz] Inonu Univ, Dept Pediat Nephrol, Fac Med, Malatya, Turkey. |
|
dc.description.abstract |
[Gimpel, Charlotte] Univ Freiburg, Med Ctr, Dept Gen Pediat Adolescent Med & Neonatol, Fac Med, Freiburg, Germany. |
|
dc.description.abstract |
[Ertan, Pelin] Celal Bayar Univ, Dept Pediat Nephrol, Manisa, Turkey. |
|
dc.description.abstract |
[Yavascan, Onder] Univ Hlth Sci, Izmir Tepecik Training & Res Hosp, Dept Pediat Nephrol, Izmir, Turkey. |
|
dc.description.abstract |
[Querfeld, Uwe] Charite, Dept Pediat Nephrol, Berlin, Germany. |
|
dc.description.abstract |
[Wuehl, Elke; Schaefer, Franz] Heidelberg Univ Hosp, Ctr Pediat & Adolescent Med, Div Pediat Nephrol, Heidelberg, Germany. |
|
dc.description.abstract |
[Arbeiter, Klaus] Univ Childrens Hosp Vienna, Pediat Nephrol, Vienna, Austria. |
|
dc.description.abstract |
[Rosales, Alejandra] Med Univ, Dept Pediat 1, Innsbruck, Austria. |
|
dc.description.abstract |
[Dusek, Jiri] Univ Hosp Motol, Prague, Czech Republic. |
|
dc.description.abstract |
[Zaloszyc, Ariane] Hop Hautepierre, Pole Medicochirug Pediat, Strasbourg, France. |
|
dc.description.abstract |
[Gellermann, Jutta; Querfeld, Uwe] Charite Campus Virchow Klinikum, Pediat Nephrol, Berlin, Germany. |
|
dc.description.abstract |
[Liebau, Max; Weber, Lutz] Univ Childrens Hosp, Pediat Nephrol Immunol & Hypertensiol, Cologne, Germany. |
|
dc.description.abstract |
[Muschiol, Evelin] Univ Childrens Hosp, Pediat Nephrol, Erlangen, Germany. |
|
dc.description.abstract |
[Buescher, Rainer] Univ Childrens Hosp, Pediat Nephrol, Essen, Germany. |
|
dc.description.abstract |
[Oh, Jun] UKE Univ Childrens Hosp, Pediat Nephrol, Hamburg, Germany. |
|
dc.description.abstract |
[Melk, Anette; Thurn-Valassina, Daniela; Haffner, Dieter] Hannover Med Sch, Pediat Nephrol, Hannover, Germany. |
|
dc.description.abstract |
[Schaefer, Franz] Ctr Children & Adolescents, Div Pediat Nephrol, Heidelberg, Germany. |
|
dc.description.abstract |
[Gimpel, Charlotte] Ctr Pediat & Adolescent Med, Div Pediat Nephrol, Freiburg, Germany. |
|
dc.description.abstract |
[John, Ulrike] Ctr Pediat & Adolescent, Div Pediat & Nephrol, Jena, Germany. |
|
dc.description.abstract |
[Wygoda, Simone] Town Hosp St Georg, Childrens Dialysis Ctr, Leipzig, Germany. |
|
dc.description.abstract |
[Jeck, Nikola] KfH Kidney Ctr Children, Marburg, Germany. |
|
dc.description.abstract |
[Wigger, Marianne] Univ Childrens Hosp, Pediat Nephrol, Rostock, Germany. |
|
dc.description.abstract |
[Testa, Sara] Policlin Milano, Pediat Nephrol & Dialysis, Osped Maggiore, Milan, Italy. |
|
dc.description.abstract |
[Murer, Luisa] Dipartimento Pediatria Salus Pueri, Dept Pediat, Dialysis & Transplantat, Padua, Italy. |
|
dc.description.abstract |
[Matteucci, Chiara] Osped Pediat Bambino Gesu, Div Nefrol & Dialisi, Rome, Italy. |
|
dc.description.abstract |
[Azukaitis, Karolis; Jankauskiene, Augustina] Vilnius Univ, Clin Pediat, Vilnius, Lithuania. |
|
dc.description.abstract |
[Drozdz, Dorota] PA Childrens Hosp, Dialysis Unit, Krakow, Poland. |
|
dc.description.abstract |
[Lugani, Francesca] Inst Giannina Gaslini, Pediat Nephrol, Genoa, Italy. |
|
dc.description.abstract |
[Zurowska, Aleksandra] Univ Med Sch, Dept Pediat & Adolescent Nephrol, Gdansk, Poland. |
|
dc.description.abstract |
[Zaniew, Marcin] Pomeranian Acad Med, Clin Pediat, Szczecin, Poland. |
|
dc.description.abstract |
[Litwin, Mieczyslaw; Nimierska, Anna] Childrens Mem Hlth Inst, Nephrol Kidney Transplantat & Hypertens, Warsaw, Poland. |
|
dc.description.abstract |
[Teixeira, Ana] Hosp Sao Joao, Serv Pediat, Porto, Portugal. |
|
dc.description.abstract |
[Paripovic, Dusan; Peco-Antic, Amira] Univ Childrens Hosp, Belgrade, Serbia. |
|
dc.description.abstract |
[Laube, Guido] Univ Childrens Hosp, Nephrol, Zurich, Switzerland. |
|
dc.description.abstract |
[Bayazit, Aysun; Anarat, Ali] Cukurova Univ, Cocuk Nefrolojisi Bilim Dali, Tip Fak, Adana, Turkey. |
|
dc.description.abstract |
[Duzova, Ali; Bilginer, Yelda] Hacettepe Univ, Pediat Nephrol, Ankara, Turkey. |
|
dc.description.abstract |
[Canpolat, Nur; Civilibal, Mahmut; Caliskan, Salim] Cerrahpasa Med Fac, Pediat Nephrol, Istanbul, Turkey. |
|
dc.description.abstract |
[Mir, Sevgi; Soezeri, Betul] Ege Univ, Pediat Nephrol, Izmir, Turkey. |
|
dc.description.abstract |
[Kranz, Brigitta] Univ Childrens Hosp, Pediat Nephrol, Munster, Germany. |
|
dc.description.abstract |
[Mencarelli, Francesca] St Orsola Malphighi Hosp, Dept Pediat, Bologna, Italy. |
|
dc.description.abstract |
[Dorn, Brigitte] Inselspital Childrens Hosp, Bern, Switzerland. |
|
dc.description.abstract |
[Yalcinkaya, Fatos] Univ Tip Fac Med Cebeci Kampusu Cocuk, Pediat Nephrol, Ankara, Turkey. |
|
dc.description.abstract |
[Baskin, Esra] Baskent Univ, Fac Med, Ankara, Turkey. |
|
dc.description.abstract |
[Cakar, Nilgun] Diskapi Childrens Hosp, Ankara, Turkey. |
|
dc.description.abstract |
[Soylemezoglu, Oguz] Gazi Univ Hosp, Pediat Nephrol, Ankara, Turkey. |
|
dc.description.abstract |
[Emre, Sevinc] Istanbul Fac Med, Dept Pediat Nephrol, Capa, Turkey. |
|
dc.description.abstract |
[Candan, Cengiz] Goztepe Educ & Res Hosp, Pediat Nephrol, Istanbul, Turkey. |
|
dc.description.abstract |
[Kiyak, Aysel] Bakirkoy Childrens Hosp, Pediat Nephrol, Istanbul, Turkey. |
|
dc.description.abstract |
[Ozcelik, Gul] Sisli Educ & Res Hosp, Pediat Nephrol, Istanbul, Turkey. |
|
dc.description.abstract |
[Alpay, Harika] Marmara Univ, Pediat Nephrol, Med Fac, Istanbul, Turkey. |
|
dc.description.abstract |
[Shroff, Rukshana] Great Ormond St Hosp Sick Children, Nephrol, London, England. |
|
dc.description.abstract |
[Rachin, Bruno] Univ Hop Femme Mere Enfant, Serv Nephrol Pediat, Lyon, France. |
|
dc.description.abstract |
[Harambat, Jerome] Ctr Reference Malad Renales Rares Sud Quest, Serv Pediat, Bordeaux, France. |
|
dc.description.abstract |
[Erdogan, Hakan] Dortcelik Childrens Hosp, Bursa, Turkey. |
|
dc.description.abstract |
[Donmez, Osman] Uludag Univ, Bursa, Turkey. |
|
dc.description.abstract |
[Balat, Ayse] Gaziantep Univ, Dept Pediat Nephrol, Gaziantep, Turkey. |
|
dc.description.abstract |
[Aksu, Nejat] Tepecik Training & Res Hosp, Izmir, Turkey. |
|
dc.description.abstract |
[Tabel, Yilmaz] Inonu Univ, Dept Pediat Nephrol, Med Sch, Malatya, Turkey. |
|
dc.description.abstract |
[Ertan, Pelin] Celal Bayar Univ, Pediat Nephrol Dept, Manisa, Turkey. |
|
dc.description.abstract |
[Yilmaz, Ebru] Sanliurfa Childrens Hosp, Pediat Nephrol, Sanliurfa, Turkey. |
|
dc.description.abstract |
[Anarat, Ali] Cukurova Univ, Sch Med, Adana, Turkey. |
|
dc.description.abstract |
[Bakkaloglu, Aysin; Ozaltin, Fatih] Hacettepe Univ, Fac Med, Ankara, Turkey. |
|
dc.description.abstract |
[Gellermann, Jutta; Querfeld, Uwe] Charite Childrens Hosp, Berlin, Germany. |
|
dc.description.abstract |
[Sallay, Peter] Semmelweis Univ Budapest, Dept Pediat 1, Budapest, Hungary. |
|
dc.description.abstract |
[Drozdz, Dorota] Jagiellonian Univ, Polish Amer Childrens Hosp, Coll Med, Krakow, Poland. |
|
dc.description.abstract |
[Bonzel, Klaus-Eugen; Wingen, Anna-Margrete] Univ Hosp Essen, Essen, Germany. |
|
dc.description.abstract |
[Zurowska, Aleksandra; Balasz, Irena] Med Univ Gdansk, Dept Paediat & Adolescent Nephrol & Hypertens, Gdansk, Poland. |
|
dc.description.abstract |
[Trivelli, Antonella; Perfumo, Francesco] Giannina Gasline Inst, Genoa, Italy. |
|
dc.description.abstract |
[Mueller-Wiefel, Dirk-Erhard; Moeller, Kerstin] Univ Childrens Hosp Hamburg Eppendorf, Hamburg, Germany. |
|
dc.description.abstract |
[Offner, Gisela; Enke, Barbara] Hannover Med Sch, Childrens Hosp, Hannover, Germany. |
|
dc.description.abstract |
[Wuehl, Elke; Schaefer, Franz; Hadtstein, Charlotte; Mehls, Otto] Ctr Pediat & Adolescent Med, Heidelberg, Germany. |
|
dc.description.abstract |
[Emre, Sevinc] Istanbul Univ, Istanbul Med Fac, Capa Campus, Istanbul, Turkey. |
|
dc.description.abstract |
[Caliskan, Salim] Istanbul Univ, Cerrahpasa Fac Med, Istanbul, Turkey. |
|
dc.description.abstract |
[Mir, Sevgi] Ege Univ, Dept Pediat, Fac Med, Izmir, Turkey. |
|
dc.description.abstract |
[Wygoda, Simone] City Hosp St Georg, Leipzig, Germany. |
|
dc.description.abstract |
[Hohbach-Hohenfellner, Katharina] Univ Childrens Hosp, Mainz, Germany. |
|
dc.description.abstract |
[Jeck, Nickola; Klaus, Guenter] Philipps Univ Marburg, Dept Pediat, Marburg, Germany. |
|
dc.description.abstract |
[Testa, Sara; Ardissino, Gianluigi] Policlin Mangiagalli, IRCCS Osped Maggiore, Milan, Italy. |
|
dc.description.abstract |
[Montini, Giovanni] Univ Padua, Azienda Osped, Padua, Italy. |
|
dc.description.abstract |
[Charbit, Marina; Niaudet, Patrick] Hop Necker Enfants Malad, Paris, France. |
|
dc.description.abstract |
[Afonso, Alberto Caldas; Fernandes-Teixeira, Ana] Hosp Sao Joao, Porto, Portugal. |
|
dc.description.abstract |
[Dusek, Jiri] Univ Hosp Motol, Dept Pediat, Prague, Czech Republic. |
|
dc.description.abstract |
[Matteucci, Chiara; Picca, Stefano] Osped Pediat Bambino Gesu, Rome, Italy. |
|
dc.description.abstract |
[Wigger, Marianne] Univ Childrens Hosp, Rostock, Germany. |
|
dc.description.abstract |
[Berg, Ulla B.; Celsi, Giovanni] Huddinge Univ Hosp, Karolinska Inst, Stockholm, Sweden. |
|
dc.description.abstract |
[Fischbach, Michel; Terzic, Joelle] Hop Univ Strasbourg, Pediat 1, Strasbourg, France. |
|
dc.description.abstract |
[Fydryk, Janusz; Urasinski, Tomasz] Pomeranian Acad Med, Szczecin, Poland. |
|
dc.description.abstract |
[Coppo, Rosanna; Peruzzi, Licia] Osped Infantile Regina Margherita, Turin, Italy. |
|
dc.description.abstract |
[Arbeiter, Klaus] Univ Childrens Hosp, Vienna, Austria. |
|
dc.description.abstract |
[Jankauskiene, Augustina] Vilnius Univ, Childrens Hosp, Vilnius, Lithuania. |
|
dc.description.abstract |
[Litwin, Mieczyslaw; Grenda, Ryszard] Childrens Mem Hlth Hosp, Warsaw, Poland. |
|
dc.description.abstract |
[Neuhaus, Thomas J.] Univ Childrens Hosp, Zurich, Switzerland. |
|
dc.source |
KIDNEY INTERNATIONAL |
|
dc.title |
Low levels of urinary epidermal growth factor predict chronic kidney |
|
dc.title |
disease progression in children |
|