Regional distribution of genetic mutation in lung cancer in Turkey

Abstract

Introduction: The results of standard chemotherapy in lung cancer are not very satisfactory, so it is important to identify genetic mutations that provide targeted therapies. Recent reports have suggested influences of racial difference on the frequency of mutation in lung cancer. We aimed to determine the frequency and regional distribution of genetic mutations of non-small cell lung cancer (NSCLC) in Turkey.

Materials and Methods: Regional distribution of genetic mutations in lung cancer in Turkey (REDIGMA) study was carried out as a prospective, cross-sectional, observational study in a large number of centers in which lung cancer patients were followed and could perform genetic mutation analysis on patients' biopsy materials.

Results: The 703 patients (77.7% male, mean age 63.3 +/- 12.5 years) who were diagnosed as NSCLC from 25 different centers were included in the study. Tumor samples from patients were reported as 87.1% adenocarcinoma, 6.4% squamous cell carcinoma and 6.5% other. Mutation tests were found to be positive in 18.9% of these patients. The mutations were 69.9% EGFR, 26.3% ALK, 1.6% ROS and 2.2% PDL. Mutations were higher in women and non-smokers (p < 0.000, p < 0.001). Again, the frequency of mutations in adenocarcinoma was higher in metastatic disease. There was no difference between the patient's age, area of residence, comorbidity and clinical stage and mutation frequency.

Conclusion: Our study revealed that the EGFR mutation rate in Turkey with NSCLC was similar to East European, African-American and Caucasian patients, and was lower than in East Asia.

C1 [Ozcelik, Neslihan] Recep Tayyip Erdogan Univ, Fac Med, Dept Chest Dis, Rize, Turkey.

[Aksel, Nimet; Guldaval, Filiz; Tatar, Dursun; Komurcuoglu, Berna] Dr Suat Seren Chest Dis & Chest Surg Training & R, Dept Chest Dis, Izmir, Turkey.

[Bulbul, Yilmaz; Ozlu, Tevfik; Gurel, Zerrin] Karadeniz Tech Univ, Fac Med, Dept Chest Dis, Trabzon, Turkey.

[Erdogan, Yurdanur; Senturk, Aysegul] Ataturk Chest Dis & Chest Surg Training & Res Hos, Dept Chest Dis, Ankara, Turkey.

[Gul, Sule Karabulut] Kartal Dr Lutfi Kirdar Training & Res Hosp, Dept Radiat Oncol, Istanbul, Turkey.

[Bircan, Ahmet; Erturk, Gonul Seven] Suleyman Demirel Univ, Fac Med, Dept Chest Dis, Isparta, Turkey.

[Can, Atilla; Esme, Hidir] Konya Training & Res Hosp, Dept Chest Surg, Konya, Turkey.

[Oz, Necdet; Gunduz, Seyda] Medstar Mem Hosp, Dept Chest Surg, Antalya, Turkey.

[Arinc, Sibel] Sureyyapasa Chest Dis & Chest Surg Training & Res, Dept Chest Dis, Istanbul, Turkey.

[Kilic, Talat] Inonu Univ, Fac Med, Dept Chest Dis, Malatya, Turkey.

[Kurt, Emine Bahar; Isik, Silan] Diskapi Training & Res Hosp, Dept Chest Dis, Ankara, Turkey.

[Gunay, Ersin] Afyon Kocatepe Univ, Fac Med, Dept Chest Dis, Afyon, Turkey.

[Caglayan, Benan; Iliaz, Sinem] Koc Univ, Fac Med, Dept Chest Dis, Istanbul, Turkey.

[Aydin, Derya Celebi] Balikesir Chest Dis Hosp, Dept Chest Dis, Balikesir, Turkey.

[Basyigit, Ilknur; Baris, Serap Argun] Kocaeli Univ, Fac Med, Dept Chest Dis, Kocaeli, Turkey.

[Savas, Ismail; Celik, Gokhan] Ankara Univ, Fac Med, Dept Chest Dis, Ankara, Turkey.

[Arslan, Sulhattin; Dogan, Omer Tamer; Eris, Eda] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Sivas, Turkey.

[Bayram, Mehmet] Bezmialem Vakif Univ, Fac Med, Dept Chest Dis, Istanbul, Turkey.

[Gulmez, Inci; Tutar, Nuri] Erciyes Univ, Fac Med, Dept Chest Dis, Kayseri, Turkey.

[Niksarlioglu, Elif Yelda Ozgun] Yedikule Chest Dis & Chest Surg Training & Res Ho, Dept Chest Dis, Istanbul, Turkey.

[Kaba, Erkan; Toker, Alper] Istanbul Bilim Univ, Florence Nightingale Hosp, Dept Chest Surg, Istanbul, Turkey.

[Karaoglanoglu, Selen] Ordu Univ, Fac Med, Dept Chest Dis, Ordu, Turkey.

[Ozgur, Esra Aydin] Dokuz Eylul Univ, Fac Med, Dept Occupat Dis, Izmir, Turkey.

[Ozcelik, Ali Erdem] Recep Tayyip Erdogan Univ, Fac Engn, Dept Mapping Engn, Rize, Turkey.

[Gayaf, Mine; Anar, Ceyda; Erbaycu, Ahmet Emin; Varol, Yelda] Hlth Sci Univ, Dr Suat Seren Chest Dis & Chest Surg Training & R, Izmir, Turkey.

[Ozdemirel, Tugce Sahin] Ataturk Chest Dis & Chest Surg Training & Res Hos, Ankara, Turkey.

[Oruc, Ahmet Fatih] Hlth Sci Univ, Kartal Dr Lutfi Kirdar Training & Res Hosp, Dept Radiat Oncol, Istanbul, Turkey.

[Yaman, Feride] Sureyyapasa Chest Dis & Chest Surg Training & Res, Istanbul, Turkey.

[Sariaydin, Muzaffer] Afyon Kocatepe Univ, Fac Med, Dept Chest Dis, Afyon, Turkey.