Trends of primary glomerular disease in Turkey: TSN-GOLD registry report

Abstract

Background Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. Methods Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013-2017, and 2017-current. Results A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (x 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (x 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. Conclusions In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.

C1 [Gul, Cuma Bulent; Aktas, Nimet] Bursa Yuksek Ihtisas Training & Res Hosp, Dept Nephrol, Bursa, Turkey.

[Kucuk, Mehmet; Can, Basak] Okmeydan Training & Res Hosp, Nephrol, Istanbul, Turkey.

[Ozturk, Savas] Haseki Training & Resarch Hosp, Nephrol, Istanbul, Turkey.

[Demir, Erol] Istanbul Univ Med Sch, Nephrol, Istanbul, Turkey.

[Eren, Necmi] Kocaeli Univ, Nephrol, Sch Med, Kocaeli, Turkey.

[Sumnu, Abdullah] Medipol Univ Hosp, Fac Med, Nephrol, Istanbul, Turkey.

[Seyahi, Nurhan] Cerrahpasa Univ Med Sch, Nephrol, Istanbul, Turkey.

[Gullulu, Mustafa] Uludag Univ Med Fac Hosp, Nephrol, Bursa, Turkey.

[Dede, Fatih] Ankara Numune Training & Res Hosp, Nephrol, Ankara, Turkey.

[Derici, Ulver] Gazi Univ Med Fac, Nephrol, Ankara, Turkey.

[Koc, Yener] Sisli Hamidiye Training & Res Hosp, Nephrol, Istanbul, Turkey.

[Sahin, Garip] Osmangazi Univ, Nephrol, Odunpazari, Eskisehir, Turkey.

[Oymak, Oktay] Erciyes Univ, Nephrol, Kayseri, Turkey.

[Sahin, Gulizar Manga] Sultan Abdulhamid Han Training & Res Hosp, Nephrol, Istanbul, Turkey.

[Tatar, Erhan] Bozyaka Training & Res Hosp, Nephrol, Izmir, Turkey.

[Dursun, Belda] Pamukkale Univ, Nephrol, Denizli, Turkey.

[Dheir, Hamad] Sakarya Training & Res Hosp, Nephrol, Sakarya, Turkey.

[Apaydin, Suheyla] Istanbul Sadi Konuk Training & Res Hosp, Istanbul, Turkey.

[Suleymanlar, Gultekin] Akdeniz Univ Hosp, Nephrol, Antalya, Turkey.

[Ulu, Sena] Afyon Kocatepe Univ Med Sch, Nephrol, Afyon, Turkey.

[Altinoren, Orcun] Kahramanmaras Sutcu Imam Univ, Nephrol, Kahramanmaras, Turkey.

[Kutlay, Sim] Ankara Univ, Fac Med, Nephrol, Ankara, Turkey.

[Mese, Meral] Istanbul Dr Lufti Kirdar Kartal Training & Res Ho, Nephrol, Istanbul, Turkey.

[Sahin, Idris] Inonu Univ Med Sch, Nephrol, Malatya, Turkey.

[Ustundag, Sedat] Trakya Univ Med Sch, Nephrol, Edirne, Turkey.

[Turkmen, Kultigin; Selcuk, Nedim Yilmaz] Necmettin Erbakan Univ Meram Med Sch, Nephrol, Konya, Turkey.

[Yilmaz, Mehmet Emin] Dicle Univ Med Sch, Nephrol, Diyarbakir, Turkey.

[Kazancioglu, Rumeyza Turan] Bezmialem Univ Med Sch, Nephrol, Istanbul, Turkey.

[Uzun, Ozcan; Cavdar, Caner] Dokuz Eylul Univ Med Sch, Nephrol, Izmir, Turkey.

[Candan, Ferhan] Cumhuriyet Univ Med Sch, Nephrol, Sivas, Turkey.

[Aydin, Zeki] Darica Farabi Training & Res Hosp, Nephrol, Kocaeli, Turkey.

[Oygar, Deren] Lefkosa Burhan Nalbantoglu Hosp, Nephrol, Lefkosa, Northern Cyprus, Turkey.

[Erdem, Yunus] Hacettepe Univ Med Sch, Nephrol, Ankara, Turkey.

[Paydas, Saime] Cukurova Univ Med Sch, Nephrol, Adana, Turkey.

[Taymez, Dilek] Kocaeli State Hosp, Nephrol, Kocaeli, Turkey.

[Kiykim, Ahmet] Mersin Univ Med Sch, Nephrol, Mersin, Turkey.

[Koc, Leyla] Taksim Training & Res Hosp, Nephrol, Istanbul, Turkey.

[Sezer, Siren] Baskent Univ Med Sch, Nephrol, Ankara, Turkey.

[Duranay, Murat] Ankara Ataturk Training & Res Hosp, Nephrol, Ankara, Turkey.

[Bardak, Simge] Batman State Hosp, Nephrol, Batman, Turkey.

[Altintepe, Lutfullah] Selcuk Univ Selcuklu Med Sch, Nephrol, Konya, Turkey.

[Kaya, Burcu] Marmara Univ Med Sch, Nephrol, Istanbul, Turkey.

[Azak, Alper] Balikesir Training & Res Hosp, Nephrol, Balikesir, Turkey.

[Ecder, Sebahat Alisir] Medeniyet Univ Goztepe Training & Res Hosp, Nephrol, Istanbul, Turkey.