Clinical Characteristics and Outcomes of COVID-19 Patients with

Abstract

Purpose While obesity is related to more severe outcomes of coronavirus disease 2019 (COVID-19), factors leading to poor prognosis still remain unclear. The present study evaluated the outcomes of COVID-19 patients who were overweight or obese and variables associated with severe disease in a large group of consecutive cases.

Methods A nationwide retrospective cohort study was performed using the Turkish National Healthcare Database. Demographic characteristics, laboratory tests, comorbidities, and medications of patients registered between March 11 and May 30, 2020, were recorded.

Results A total of 14,625 patients (median age:42, IQR:26 years; female 57.4%) with normal weight (34.7%), overweight (35.6%), and obesity (29.7%) were included. Hospitalization, ICU admission, intubation/mechanical ventilation, pulmonary involvement, and mortality were significantly higher in patients who were overweight or obese. In adjusted analyses, both overweight (OR, 95% CI: 1.82, 1.04-3.21; p=0.037) and obesity (OR, 95% CI: 2.69, 1.02-1.05; p<0.001) were associated with a higher intubation/mechanical ventilation rate but only obesity was associated with increased mortality (OR, 95% CI: 2.56, 1.40-4.67; p=0.002). Old age, male gender, chronic kidney disease, and high C reactive protein levels were independently associated with COVID-19 mortality in overweight or obese patients.

Conclusions COVID-19 patients who were overweight or obese were more likely to have adverse outcomes but only obesity was a predictor of mortality. Such patients should receive urgent medical attention and active management, especially the elderly, men, and people with chronic kidney disease.

C1 [Sahin, Ibrahim] Inonu Univ, Fac Med, Dept Endocrinol & Metab, Malatya, Turkey.

[Haymana, Cem; Demirci, Ibrahim; Sonmez, Alper] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Endocrinol & Metab, TR-06010 Ankara, Turkey.

[Demir, Tevfik] Dokuz Eylul Univ, Fac Med, Dept Endocrinol & Metab, Izmir, Turkey.

[Tasci, Ilker; Dagdelen, Selcuk] Univ Hlth Sci, Gulhane Fac Med, Dept Internal Med, Ankara, Turkey.

[Tasci, Ilker; Dagdelen, Selcuk] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Internal Med, Ankara, Turkey.

[Atmaca, Aysegul] Ondokuz Mayis Univ, Fac Med, Dept Endocrinol & Metab, Samsun, Turkey.

[Cakal, Erman] Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Hosp, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey.

[Ata, Naim] Minist Hlth, Dept Strategy Dev, Ankara, Turkey.

[Emral, Rifat] Ankara Univ, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey.

[Unluturk, Ugur] Hacettepe Univ, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey.

[Ertugrul, Derun] Univ Hlth Sci, Kecioren Training & Res Hosp, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey.

[Salman, Serpil; Sahin, Mustafa] Med Clin, Dept Endocrinol & Metab, Istanbul, Turkey.

[Celik, Osman] Minist Hlth, Publ Hosp Gen Directorate, Ankara, Turkey.

[Caglayan, Murat] Ankara Prov Hlth Directorate, Ankara, Turkey.

[Satman, Ilhan] Istanbul Univ, Fac Med, Dept Endocrinol & Metab, Istanbul, Turkey.

[Satman, Ilhan] Hlth Inst Turkey, Inst Publ Hlth & Chron Dis, Istanbul, Turkey.

[Sonmez, Alper] Univ Hlth Sci, Gulhane Fac Med, Dept Endocrinol & Metab, Ankara, Turkey.