dc.contributor.author |
Elmalı, Nurzat |
|
dc.contributor.author |
Baysal, Özlem |
|
dc.contributor.author |
Harma, Ahmet |
|
dc.contributor.author |
Esenkaya, İrfan |
|
dc.contributor.author |
Mızrak, Bülent |
|
dc.date.accessioned |
2017-05-29T12:04:37Z |
|
dc.date.available |
2017-05-29T12:04:37Z |
|
dc.date.issued |
2007 |
|
dc.identifier.citation |
N. Elmalı, Ö. Baysal, A. Harma, İ. Esenkaya, And B. Mızrak, “Effects Of Resveratrol İn Inflammatory Arthritis,” Inflammation, Vol. 30, No. 1–2, Pp. 1–6, Mar. 2007. |
tr_TR |
dc.identifier.uri |
https://link.springer.com/article/10.1007%2Fs10753-006-9012-0 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/6977 |
|
dc.description |
Inflammation, Vol. 30, Nos. 1Y2, April 2007 ( 2006) |
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dc.description.abstract |
Summary: Nuclear factor kappa B (NF-kB), is a pivotal transcription factor involved in the activation of the
TNF-a and IL-1b genes. Activation of NF-kB in synovial cells is a feature seen in arthritis patients.
Resveratrol, a polyphenolic, natural phytoalexin found with particularly high levels in grape skin and red
wine is potent and specific inhibitor of TNF-! and IL-1b induced NF-kB activation. We aimed to determine
the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental
rabbit inflammatory arthritis model.
Materials and methods: Arthritis was induced by intra-articular injection of three times of 50 mg
lipopolysaccharide (LPS) at day 0, 4 and 8 at 4-day intervals into the knee joints of rabbits. To the test
group, 10 mMol/kg resveratrol in the DMSO was injected in the knees at day 0 and then it was continued
once daily for 2 weeks. To the control group the same time and amount of DMSO was injected the knees of
rabbits. All rabbits were killed 1 week after the last injection and cartilage tissue and synovium were
evaluated with semiquantitative scoring histologically.
Results: According to control group in the resveratrol group, significantly decreased cartilage destruction
was determined by H&E staining (p = 0.04). Loss of matrix proteoglycan content in the cartilage was much
lower, as determined by safranin O staining (p = 0.03). We also observed marked synovial inflammation
after intra-articular injection to control knees, but not in the resveratrol treated group knees (p = 0.01).
Conclusion: This study suggests that intra-articular injection of resveratrol may protect cartilage against the
development of experimentally induced IA. |
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dc.language.iso |
eng |
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dc.publisher |
Inflammation |
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dc.relation.isversionof |
10.1007/s10753-006-9012-0 |
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dc.rights |
info:eu-repo/semantics/openAccess |
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dc.subject |
Resveratrol |
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dc.subject |
Cartilage |
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dc.subject |
Synovium |
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dc.subject |
İnflammatory arthritis |
tr_TR |
dc.title |
Effects of resveratrol in ınflammatory arthritis |
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dc.type |
article |
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dc.relation.ispartof |
Inflammation |
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dc.department |
İnönü Üniversitesi |
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dc.identifier.volume |
30 |
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dc.identifier.issue |
0 |
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dc.identifier.startpage |
1 |
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dc.identifier.endpage |
6 |
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