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Introduction: This study aims to investigate the effects of chrysin on burn healing in burned model rats. Materials and methods: Rats were burned and randomly divided into four groups. Group 1; the group whose burn wound was left to secondary healing. Group 2; the group to which bacitracin neomycin sulfate pomade was topically administered. Group 3; the group to which chrysin was administered topically and with gastric gavage. Group 4; the group was assigned as the group to which chrysin and bacitracin neomycin sulfate was administered. Results: On days 3, 7 and 14, blood samples and skin biopsies were taken. Necrosis, congestion, hemorrhage and IL-1β were found to have the lowest levels on all days when bacitracin and chrysin were administered together. This group was also found to have the lowest level of TNF-α serum levels on days 7 and 14. Conclusion: We conclude that chrysin is effective in the treatment of burn wounds when used separately, but when combined with topical bacitracin pomade application, it is more effective for healing. © 2021 A. CARBONE Editore. All rights reserved. |
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