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In this study new benzimidazolium salt as N-heterocyclic carbene precursors and their related new PEPPSI-Pd(II)–N-heterocyclic carbene (NHC) complexes 3a-e were prepared and caracterized. The structures of all compounds have been characterized by 1H NMR, 13C NMR, and IR spectroscopy, as well as elemental analysis techniques and Direct analysis in real time (DART)–time-of-flight mass spectrometry (TOF-MS), which support the proposed structures. Further confirmations of structural details were provided by a single-crystal X-ray. A single crystal of PEPPSI-Pd(II)–N-heterocyclic carbene (NHC) complex 3c shows that the coordination geometry around Pd slightly distorted square-planar geometry. Next, the PEPPSI-Pd(II)–N-heterocyclic carbene (NHC) complexes 3a-e were used as catalysts in the direct C5-arylation of 2-acetyl furan and 2-acetylthiophene with various aryl bromides. These complexes exhibited moderate to high catalytic activities and gave C–H activation selectively at the C5-position. Further, PEPPSI-Pd(II)–N-heterocyclic carbene (NHC) complexes 3a-e have been evaluated for their potential antibacterial properties against a panel of bacterial strains namely, Micrococcus luteus, Listeria monocytogenes, Salmonella Typhimurium, Staphylococcus aureus, candida albican and pseudomonas aeruginosa. In addition; these new PEPPSI-Pd(II)–N-heterocyclic carbene (NHC) complexes 3a-e were investigated for anti-oxidant activities by super oxide radical; DPPH (2,2-Diphenyl-1-picrylhydrazyl); and hydroxyl radical scavenging assays; in which most of them displayed significant antioxidant activities. Furthermore; PEPPSI-Pd(II)–N-heterocyclic carbene (NHC) complexes 3a-e were evaluated for anti-inflammatory activity by indirect haemolytic and lipoxygenase inhibition assays and revealed good activity. © 2021 Elsevier B.V. |
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