Antioxidant and cytotoxic properties of some new dipeptide-indole conjugates

dc.contributor.author	Gönül, Z.
dc.contributor.author	Öztürk, D.A.
dc.contributor.author	Küçükbay, F.
dc.contributor.author	Tekin, S.
dc.contributor.author	Tekin, Z.
dc.contributor.author	Küçükbay, H.
dc.date.accessioned	2022-10-06T12:54:41Z
dc.date.available	2022-10-06T12:54:41Z
dc.date.issued	2022
dc.identifier.issn	0022152X (ISSN)
dc.identifier.uri	http://hdl.handle.net/11616/72388
dc.description.abstract	In this study, 10 new indole-dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) and MCF-7 (breast cancer cell line) cells. Among compounds, 5 and 10 showed better activity against A2780 cell lines than the standard drug docatexel at 0.1 and 1 μM concentrations, while only compound 5 showed better activity than docatexel, the MCF-7 cell line at 0.1 and 1 μM concentrations. The antioxidant potencies of the compounds were low in both the DPPH and iron reducing power methods tested when compared to standard antioxidants used in this work. © 2022 Wiley Periodicals LLC.
dc.source	Journal of Heterocyclic Chemistry
dc.title	Antioxidant and cytotoxic properties of some new dipeptide-indole conjugates

Bu öğenin dosyaları:

Dosyalar	Boyut	Biçim	Göster
Bu öğe ile ilişkili dosya yok.