dc.contributor.author | Efe, C | |
dc.contributor.author | Dhanasekaran, R | |
dc.contributor.author | Lammert, C | |
dc.contributor.author | Ebik, B | |
dc.contributor.author | Higuera-de la Tijera, F | |
dc.contributor.author | Aloman, C | |
dc.contributor.author | Caliskan, AR | |
dc.contributor.author | Peralta, M | |
dc.contributor.author | Gerussi, A | |
dc.contributor.author | Massoumi, H | |
dc.contributor.author | Catana, AM | |
dc.contributor.author | Torgutalp, M | |
dc.contributor.author | Purnak, T | |
dc.contributor.author | Rigamonti, C | |
dc.contributor.author | Aldana, AJG | |
dc.contributor.author | Khakoo, N | |
dc.contributor.author | Kacmaz, H | |
dc.contributor.author | Nazal, L | |
dc.contributor.author | Frager, S | |
dc.contributor.author | Demir, N | |
dc.contributor.author | Irak, K | |
dc.contributor.author | Ellik, ZM | |
dc.contributor.author | Balaban, Y | |
dc.contributor.author | Atay, K | |
dc.contributor.author | Eren, F | |
dc.contributor.author | Cristoferi, L | |
dc.contributor.author | Batibay, E | |
dc.contributor.author | Urzua, A | |
dc.contributor.author | Snijders, R | |
dc.contributor.author | Kiyici, M | |
dc.contributor.author | Akyildiz, M | |
dc.contributor.author | Ekin, N | |
dc.contributor.author | Carr, RM | |
dc.contributor.author | Harputluoglu, M | |
dc.contributor.author | Hatemi, I | |
dc.contributor.author | Mendizabal, M | |
dc.contributor.author | Silva, M | |
dc.contributor.author | Idilman, R | |
dc.contributor.author | Silveira, M | |
dc.contributor.author | Drenth, JPH | |
dc.contributor.author | Assis, DN | |
dc.contributor.author | Bjornsson, E | |
dc.contributor.author | Boyer, JL | |
dc.contributor.author | Invernizzi, P | |
dc.contributor.author | Levy, C | |
dc.contributor.author | Schiano, TD | |
dc.contributor.author | Ridruejo, E | |
dc.contributor.author | Wahlin, S | |
dc.date.accessioned | 2022-10-11T12:58:51Z | |
dc.date.available | 2022-10-11T12:58:51Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://hdl.handle.net/11616/74868 | |
dc.description.abstract | Background and Aims Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking. | |
dc.description.abstract | Approach and Results We performed a retrospective study on patients with AIH and COVID-19 from 34 centers in Europe and the Americas. We analyzed factors associated with severe COVID-19 outcomes, defined as the need for mechanical ventilation, intensive care admission, and/or death. The outcomes of patients with AIH were compared to a propensity score-matched cohort of patients without AIH but with chronic liver diseases (CLD) and COVID-19. The frequency and clinical significance of new-onset liver injury (alanine aminotransferase > 2 x the upper limit of normal) during COVID-19 was also evaluated. We included 110 patients with AIH (80% female) with a median age of 49 (range, 18-85) years at COVID-19 diagnosis. New-onset liver injury was observed in 37.1% (33/89) of the patients. Use of antivirals was associated with liver injury (P = 0.041; OR, 3.36; 95% CI, 1.05-10.78), while continued immunosuppression during COVID-19 was associated with a lower rate of liver injury (P = 0.009; OR, 0.26; 95% CI, 0.09-0.71). The rates of severe COVID-19 (15.5% versus 20.2%, P = 0.231) and all-cause mortality (10% versus 11.5%, P = 0.852) were not different between AIH and non-AIH CLD. Cirrhosis was an independent predictor of severe COVID-19 in patients with AIH (P < 0.001; OR, 17.46; 95% CI, 4.22-72.13). Continuation of immunosuppression or presence of liver injury during COVID-19 was not associated with severe COVID-19. | |
dc.description.abstract | Conclusions This international, multicenter study reveals that patients with AIH were not at risk for worse outcomes with COVID-19 than other causes of CLD. Cirrhosis was the strongest predictor for severe COVID-19 in patients with AIH. Maintenance of immunosuppression during COVID-19 was not associated with increased risk for severe COVID-19 but did lower the risk for new-onset liver injury during COVID-19. | |
dc.source | HEPATOLOGY | |
dc.title | Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An | |
dc.title | International Multicenter Study |
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