dc.contributor.author |
Boubakri, L |
|
dc.contributor.author |
Al-Ayed, AS |
|
dc.contributor.author |
Mansour, L |
|
dc.contributor.author |
Abutaha, N |
|
dc.contributor.author |
Harrath, AH |
|
dc.contributor.author |
Ozdemir, I |
|
dc.contributor.author |
Yasar, S |
|
dc.contributor.author |
Hamdi, N |
|
dc.date.accessioned |
2022-10-11T13:33:18Z |
|
dc.date.available |
2022-10-11T13:33:18Z |
|
dc.date.issued |
2019 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/76309 |
|
dc.description.abstract |
Pd(II)-bis(NHC) complexes (where NHC = N-heterocyclic carbene) bearing asymmetrically and symmetrically substituted NHC-ligand have been synthesized via deprotonation of 5,6-dimethylbenzimidazolium salts. The NHC precursors have been achieved via the two step N-alkylation of 5,6-dimethylbenzimidazole. The resultant salts were deprotonated with PdCl2 and K2CO3 in dry THF for 2(a-e). The obtained complexes were identified and characterized by H-1 and C-13 NMR, FT-IR, DART-TOF mass spectrometry and elemental analysis. These new Pd(II)-bis(NHC) complexes were applied as catalyst precursors for Suzuki-Miyaura cross-coupling reactions of aryl bromides and chlorides with phenylboronic acid to afford the corresponding products in good yields. This catalytic reaction was evaluated in the presence of KOtBu/toluene. The antibacterial activities of 2(a-e) were investigated against Gram (+)/(-) bacteria using the agar dilution procedure. The antibacterial activities of 2 vary with the nature of the ligands; MIC values of 2(a-e) were determined. |
|
dc.source |
JOURNAL OF COORDINATION CHEMISTRY |
|
dc.title |
Bioactive NHC-derived palladium complexes: synthesis, catalytic activity |
|
dc.title |
for the Suzuki-Miyaura coupling of aryl chlorides and bromides and their |
|
dc.title |
antibacterial activities |
|