dc.contributor.author |
Harputluoğlu, Muhsin Murat Muhip |
|
dc.contributor.author |
Demirel, Ulvi |
|
dc.contributor.author |
Yücel, Neslihan |
|
dc.contributor.author |
Karadağ, Neşe |
|
dc.contributor.author |
Temel, İsmail |
|
dc.contributor.author |
Fırat, Serpil |
|
dc.contributor.author |
Ara, Cengiz |
|
dc.contributor.author |
Aladağ, Murat |
|
dc.date.accessioned |
2017-09-08T08:40:27Z |
|
dc.date.available |
2017-09-08T08:40:27Z |
|
dc.date.issued |
2006 |
|
dc.identifier.citation |
Harputluoğlu, M. M. M. Demirel, U. Yücel, N. Karadağ, N. Temel, İ. Fırat, S. Ara, C. Aladağ, M. (2006). The effects of Gingko biloba extract on acetic acid induced colitis in rats. Turk J Gastroenterol. 17 (3): 177-182. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/11616/7736 |
|
dc.description.abstract |
Background/aims: Gingko biloba is an antioxidant substance
which has antagonistic activity on platelet-activating factor. We
aimed to investigate the antioxidant effect and the histopathologic
changes caused by Gingko biloba on acetic acid-induced
colitis. Methods: Totally 22 rats were divided into three groups.
Group 1 (n=7) served as the control group. Group 2 (n=7) and
Group 3 (n=8) were given 2 ml/day of 4% acetic acid by intracolonic
instillation for three days. Gingko biloba (100 mg/kg)
was then given only to Group 3 intraperitoneally for three days.
Oxidative stress was assessed by determinate tissue and serum
malondialdehyde (MDA) levels, and colonic damage was assessed
by histologic examination. Results: Depth of necrosis, extent
of necrosis, degree of inflammation, extent of inflammation,
fibrosis and total histologic scores in Group 2 were significantly
higher than in the control group (p<0.05). The same parameters
were lower in Group 3 versus Group 2, but the difference was
not significant. Tissue and serum MDA levels in Group 2 were
significantly higher than Group 1 (p<0.01 and 0.05, respectively).
Again, the same parameters in Group 3 were lower than
in Group 2, but the difference was not significant statistically.
Conclusions: Gingko biloba did not significantly affect histopathological
and oxidative stress parameters in experimental
colitis. |
tr_TR |
dc.description.abstract |
Amaç: Gingko biloba platelet aktivatör faktör antagonistik etkiye
sahip antioksidan bir maddedir. Biz ratlarda asetik asit
ile oluflturulmufl kolitte Gingko biloba’nın antioksidan ve histopatolojik
etkilerini arafltırmayı amaçladık. Yöntem: Toplam
22 rat üç gruba ayrıldı. Grup 1 (n=7) kontrol grubuydu. Grup
2 (n=7) ve grup 3 (n=8)’e 3 gün kolon içerisine rektal yoldan 2
ml/gün %4 asetik asit verildi. Grup 3’e efl zamalı 3 gün 100
mg/kg intraperitoneal flekilde Gingko biloba verildi. Oksidatif
stres doku ve serumda malondialdehit düzeylerinin ölçülmesiyle,
kolon hasarı ise histopatolojik incelemeyle de¤erlendirildi.
Bulgular: Grup 2’de nekroz derinli¤i, nekroz yaygınlı¤ı, inflamasyon
derecesi, infalamsyon yaygınlı¤ı, fibrozis ve total histolojik
skorlar kontrol grubundan anlamlı yüksekti (p<0.05). Aynı
parametreler grup 3’de grup 2’den daha düflüktü ancak fark
anlamlı de¤ildi. Grup 2’de doku ve serum malondialdehit dü-
zeyleri grup 1’den anlamlı yüksekti (p<0.05). Aynı parametreler
grup 3 de grup 2’den daha düflüktü ancak fark istatistiksel olarak
anlamsızdı. Sonuç: Gingko biloba deneysel kolitte histopatolojik
ve oksidatif stres parametrelerini anlamlı etkilemedi. |
tr_TR |
dc.language.iso |
eng |
tr_TR |
dc.publisher |
Turk J Gastroenterol |
tr_TR |
dc.rights |
info:eu-repo/semantics/openAccess |
tr_TR |
dc.title |
The effects of Gingko biloba extract on acetic acid induced colitis in rats |
tr_TR |
dc.title.alternative |
Ratlarda asetik asit ile oluflturulmufl kolitte Gingko biloba ekstraktının etkileri |
tr_TR |
dc.type |
article |
tr_TR |
dc.relation.ispartof |
Turk J Gastroenterol |
tr_TR |
dc.department |
İnönü Üniversitesi |
tr_TR |
dc.authorid |
109416 |
tr_TR |
dc.identifier.volume |
17 |
tr_TR |
dc.identifier.issue |
3 |
tr_TR |
dc.identifier.startpage |
177 |
tr_TR |
dc.identifier.endpage |
182 |
tr_TR |