dc.contributor.author |
Akkoc, S |
|
dc.contributor.author |
Kayser, V |
|
dc.contributor.author |
Ilhan, IO |
|
dc.contributor.author |
Hibbs, DE |
|
dc.contributor.author |
Gok, Y |
|
dc.contributor.author |
Williams, PA |
|
dc.contributor.author |
Hawkins, B |
|
dc.contributor.author |
Lai, F |
|
dc.date.accessioned |
2022-10-13T10:45:28Z |
|
dc.date.available |
2022-10-13T10:45:28Z |
|
dc.date.issued |
2017 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/78080 |
|
dc.description.abstract |
Benzimidazolium salts and their Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) palladium N-heterocyclic carbene (Pd-NHC) based complexes have been synthesized and their structures characterized with a number of different instrumental techniques including NMR (H-1 and C-13), IR, EI-MS (for 2), X-ray (for 1, 2 and 4) and elemental analysis. The cytotoxicity of all the compounds was tested using the human embryonic kidney (HEK-293T), human breast epithelial adenocarcinoma (MDA-MB-231), and human colon epithelial colorectal adenocarcinoma (DLD-1) cell lines. The benzimidazolium salts (2-5) had more cytotoxic activity against cancerous cells compared with the metal complexes (6-9), which curiously exhibited no activity against any of the cell lines. Based on the IC50 values, compound 5 displayed the highest in vitro anticancer activity among compounds 2-9. Crown Copyright (C) 2017 Published by Elsevier B.V. All rights reserved. |
|
dc.description.abstract |
C1 [Akkoc, Senem; Kayser, Veysel; Hibbs, David E.; Williams, Peter A.; Hawkins, Bryson; Lai, Felcia] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia. |
|
dc.description.abstract |
[Akkoc, Senem; Ilhan, Ilhan Ozer] Erciyes Univ, Fac Sci, Dept Chem, Talas St, TR-38039 Kayseri, Turkey. |
|
dc.description.abstract |
[Gok, Yetkin] Inonu Univ, Fac Arts & Sci, Dept Chem, TR-44280 Malatya, Turkey. |
|
dc.source |
JOURNAL OF ORGANOMETALLIC CHEMISTRY |
|
dc.title |
New compounds based on a benzimidazole nucleus: synthesis, |
|
dc.title |
characterization and cytotoxic activity against breast and colon cancer |
|
dc.title |
cell lines |
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