Impact of adjuvant treatment modalities on survival outcomes in

Abstract

Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC).

Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013.

Results: Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered.

Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.

C1 [Turan, Nedim; Babacan, Nalan Akgul] Cumhuriyet Univ, Fac Med, Dept Med Oncol, TR-58140 Sivas, Turkey.

[Benekli, Mustafa; Algin, Efnan; Cetin, Bulent; Coskun, Ugur; Uner, Aytug; Ozet, Ahmet; Buyukberber, Suleyman] Gazi Univ, Fac Med, Dept Med Oncol, TR-06560 Ankara, Turkey.

[Unal, Olcun Umit; Unek, Ilkay Tugba; Oztop, Ilhan] Dokuz Eylul Univ, Fac Med, Dept Med Oncol, TR-35340 Izmir, Turkey.

[Tastekin, Didem] Necmettin Erbakan Univ, Fac Med, Dept Med Oncol, TR-42080 Konya, Turkey.

[Dane, Faysal] Marmara Univ, Fac Med, Dept Med Oncol, TR-34000 Istanbul, Turkey.

[Ulger, Sukran] Gazi Univ, Fac Med, Dept Radiat Oncol, TR-06560 Ankara, Turkey.

[Eren, Tulay; Ozdemir, Nuriye] Numune Educ & Res Hosp, Dept Med Oncol, TR-06100 Ankara, Turkey.

[Topcu, Turkan Ozturk] Karadeniz Tech Univ, Fac Med, Dept Med Oncol, TR-61000 Trabzon, Turkey.

[Turkmen, Esma] Trakya Univ, Fac Med, Dept Med Oncol, TR-22020 Edirne, Turkey.

[Tufan, Gulnihal] Rize Educ & Res Hosp, Dept Med Oncol, TR-53200 Rize, Turkey.

[Urakci, Zuhat] Dicle Univ, Fac Med, Dept Med Oncol, TR-21280 Diyarbakir, Turkey.

[Ustaalioglu, Basak Oven; Ercelep, Ozlem Balvan] Dr Lutfi Kirdar Kartal Educ & Res Hosp, Dept Med Oncol, TR-34668 Istanbul, Turkey.

[Uysal, Ozlem Sonmez] Sakarya Educ & Res Hosp, Dept Med Oncol, TR-54050 Sakarya, Turkey.

[Taskoylu, Burcu Yapar] Pamukkale Univ, Fac Med, Dept Med Oncol, TR-20070 Denizli, Turkey.

[Aksoy, Asude] Inonu Univ, Fac Med, Dept Med Oncol, TR-44315 Malatya, Turkey.

[Canhoroz, Mustafa] Firat Univ, Fac Med, Dept Med Oncol, TR-23200 Elazig, Turkey.

[Demirci, Umut; Helvaci, Kaan] Dr Abdurrahman Yurtaslan Educ & Res Hosp, Dept Med Oncol, TR-06200 Ankara, Turkey.

[Dogan, Erkan] Yuzuncu Yil Univ, Fac Med, Dept Med Oncol, TR-65080 Van, Turkey.

[Berk, Veli] Erciyes Univ, Fac Med, Dept Med Oncol, TR-38000 Kayseri, Turkey.

[Balakan, Ozan] SutcuImam Univ, Fac Med, Dept Med Oncol, TR-46100 Kahramanmaras, Turkey.

[Ekinci, Ahmet Siyar] Diyarbakir Educ & Res Hosp, Dept Med Oncol, TR-21010 Diyarbakir, Turkey.

[Uysal, Mukremin] Afyon Kocatepe Univ, Fac Med, Dept Med Oncol, TR-03200 Afyon, Turkey.

[Petekkaya, Ibrahim] Dr Ersin Arslan State Hosp, Dept Med Oncol, TR-27010 Gaziantep, Turkey.

[Ozturk, Selcuk Cemil] Adiyaman Univ, Educ & Res Hosp, Dept Med Oncol, TR-02040 Adiyaman, Turkey.

[Tonyali, Onder] Mustafa Kemal Univ, Fac Med, Dept Med Oncol, TR-31070 Antakya, Turkey.

[Aldemir, Mehmet Naci] Ataturk Univ, Fac Med, Dept Med Oncol, TR-25240 Erzurum, Turkey.