dc.contributor.author |
Aytemur, ZA |
|
dc.contributor.author |
Hacievliyagil, SS |
|
dc.contributor.author |
Iraz, M |
|
dc.contributor.author |
Samdanci, E |
|
dc.contributor.author |
Ozerol, E |
|
dc.contributor.author |
Kuku, I |
|
dc.contributor.author |
Nurkabulov, Z |
|
dc.contributor.author |
Yildiz, K |
|
dc.date.accessioned |
2022-10-19T07:34:00Z |
|
dc.date.available |
2022-10-19T07:34:00Z |
|
dc.date.issued |
2012 |
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dc.identifier.uri |
http://hdl.handle.net/11616/81027 |
|
dc.description.abstract |
Objective: Prostacyclin (PGI2) has been shown to inhibit the expression of pro-inflammatory and pro-fibrotic mediators in pulmonary fibrosis. In this study, we aimed to test the preventive effects of intraperitoneally administered iloprost, a stable PGI2 analog, on bleomycin-induced pulmonary fibrosis in rats and to compare the effects of iloprost with the effects of methylprednisolone, a traditional therapy. |
|
dc.description.abstract |
Methods: Rats were randomly allocated into four groups: 1. Saline alone (n = 6); 2. Bleomycin + placebo (n = 7); 3. Bleomycin + methyl-prednisolone (n = 7); 4. Bleomycin + iloprost (n = 7). Fibrotic changes in the lungs were demonstrated by analyzing the cellular composition of bronchoalveolar lavage fluid, histological evaluation and lung hydroxyproline content. |
|
dc.description.abstract |
Results: Fibrosis was made in the lungs of rats by bleomycin experimentally. Fibrosis scores in the methyl-prednisolone and the iloprost groups were significantly lower than in the placebo group (p < 0.05). Furthermore, the score of the iloprost group was significantly lower than the score of the methyl-prednisolone group. The hydroxyproline content was significantly less in the methyl-prednisolone and the iloprost groups (p < 0.05). In the placebo group, the neutrophil percentage in bronchoalveolar lavage was significantly higher than in the other groups, whereas the macrophage percentage in placebo group was significantly lower (p < 0.05). |
|
dc.description.abstract |
Conclusion: Iloprost has protective effect on the pulmonary fibrosis induced by bleomycin and it may be more effective in decreasing fibrotic changes than methyl-prednisolone. (C) 2011 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S. L. All rights reserved. |
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dc.description.abstract |
C1 [Aytemur, Z. Ayfer; Hacievliyagil, S. Savas] Inonu Univ, Fac Med, Dept Pulm Dis, Malatya, Turkey. |
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dc.description.abstract |
[Iraz, M.] Bezmialem Univ, Fac Med, Dept Pharmacol Dis, Istanbul, Turkey. |
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dc.description.abstract |
[Samdanci, E.; Nurkabulov, Z.; Yildiz, K.] Inonu Univ, Fac Med, Dept Pathol, Malatya, Turkey. |
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dc.description.abstract |
[Ozerol, E.] Inonu Univ, Fac Med, Dept Biochem, Malatya, Turkey. |
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dc.description.abstract |
[Kuku, I.] Inonu Univ, Fac Med, Dept Haematol, Malatya, Turkey. |
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dc.source |
REVISTA PORTUGUESA DE PNEUMOLOGIA |
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dc.title |
Effects of iloprost on bleomycin-induced pulmonary fibrosis in rats |
|
dc.title |
compared with methyl-prednisolone |
|