dc.contributor.author |
Yagmurca, M |
|
dc.contributor.author |
Ucar, M |
|
dc.contributor.author |
Fadillioglu, E |
|
dc.contributor.author |
Erdogan, H |
|
dc.contributor.author |
Ozturk, F |
|
dc.date.accessioned |
2022-10-19T09:38:56Z |
|
dc.date.available |
2022-10-19T09:38:56Z |
|
dc.date.issued |
2009 |
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dc.identifier.uri |
http://hdl.handle.net/11616/82394 |
|
dc.description.abstract |
Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world. causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by N omega-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA. |
|
dc.description.abstract |
Materials and Methods: Male Sprague-Dawley rats were divided into seven groups: control, ASA, ASA+L-NAME, ASA+L-Arg, ASA+L-Arg+L-NAME, only L-NAME. and only L-Arg groups. After administration of the drugs, the rats were decapitated and their stomachs were removed and fixed in 10% neutral-buffered formalin solution. |
|
dc.description.abstract |
Results: Mucosal erosion, intramucosal hemorrhage, inflammatory cell infiltration, gland cell detachment, and necrosis were observed in the ASA group. It was demonstrated that L-Arg administration decreased the gastric mucosal injury, whereas L-NAME administration increased the extent and severity of the gastric injury induced by ASA. L-Arg or L-NAME administration alone did not affect gastric mucosa. |
|
dc.description.abstract |
Conclusions: We concluded that NO may have protective effects on gastric mucosal injury induced by ASA. |
|
dc.description.abstract |
C1 [Yagmurca, Murat] Afyon Kocatepe Univ, Fac Med, Dept Histol Embryol, Afyon, Turkey. |
|
dc.description.abstract |
[Ucar, Muharrem] Inonu Univ, Fac Med, Dept Anesthesiol, Malatya, Turkey. |
|
dc.description.abstract |
[Fadillioglu, Ersin] Hacettepe Univ, Fac Med, Dept Physiol, TR-06100 Ankara, Turkey. |
|
dc.description.abstract |
[Erdogan, Hasan] Gaziosmanpasa Univ, Fac Med, Dept Physiol, Tokat, Turkey. |
|
dc.description.abstract |
[Ozturk, Feral] Inonu Univ, Fac Med, Dept Histol Embryol, Malatya, Turkey. |
|
dc.source |
TURKISH JOURNAL OF MEDICAL SCIENCES |
|
dc.title |
The Effects of Nitric Oxide on Rat Stomach Injury Induced by |
|
dc.title |
Acetylsalicylic Acid |
|