dc.contributor.author |
Kirimlioglu, V |
|
dc.contributor.author |
Karakayali, H |
|
dc.contributor.author |
Turkoglu, S |
|
dc.contributor.author |
Haberal, M |
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dc.date.accessioned |
2022-10-19T11:01:31Z |
|
dc.date.available |
2022-10-19T11:01:31Z |
|
dc.date.issued |
2008 |
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dc.identifier.uri |
http://hdl.handle.net/11616/82556 |
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dc.description.abstract |
This experimental study investigated the antioxidant status of rats after resveratrol (R) treatment following 70% partial hepatectomy. Thirty Wistar albino rats (200 to 250 g) were devided among: groups A and B (n = 10 each) underwent laparotomy and 70% partial hepatectomy (PH). Whereas rats in group A received resveratrol 60 mg/d per nasogastric tube for 7 days before and 3 days after PH (PH + R), those in group B underwent PH only. Rats in group C (n = 10) were subjected to a sham operation. Significant increases in tissue levels of reduced glutathione (GSH) and decreased malondialdehyde (MDA) levels were observed in the PH group receiving R compared with those of the PH group (P < .001 for all). Comparison of these parameters with those of the sham group revealed significantly higher tissue levels of GSH and lower MDA levels among sham-operated compared with PH + R and PH groups (P < .001 for all). Concerning the NO levels, a trend to a slightly decrease was observed in the PH + R group (P < .06). Interleukin-6 levels showed significant decreases in both PH + R and PH groups (P < .001 and P < .05, respectively). The tissue GSH levels were slightly decreased in PH + R (P < .05), and decreased in the PH group compared with the controls (P = .002). We have suggested that patients undergoing living donor liver transplantation would likely benefit from prophylactic treatment with foods having resveratrol. |
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dc.description.abstract |
C1 [Kirimlioglu, V.; Karakayali, H.; Turkoglu, S.; Haberal, M.] Inonu Univ, Malatya, Turkey. |
|
dc.description.abstract |
[Kirimlioglu, V.; Karakayali, H.; Turkoglu, S.; Haberal, M.] Baskent Univ, Fac Med, TR-06490 Ankara, Turkey. |
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dc.source |
TRANSPLANTATION PROCEEDINGS |
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dc.title |
Effect of resveratrol on oxidative stress enzymes in rats subjected to |
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dc.title |
70% partial hepatectomy |
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