Pathologic hepatic Tc-99m-MDP uptake in polyostotic fibrous dysplasia

Abstract

Fibrous dysplasia of bone is a congenital, sporadic developmental disorder characterized by immature fibrous connective tissue and bone deformities. Hepatic Tc-99m-MDP uptake is a rare, serendipitous finding during bone scanning studies. The present patient was a 25-year-old male who had severe polyostotic fibrous dysplasia. On Tc-99m-MDP (methylene diphosphonate) bone scintigraphy, increased activity accumulations were seen on multiple ribs, vertebrae and base of the cranium. In addition, diffuse increased pathologic uptake of Tc-99m-MDP in the liver was shown. Intravenous pamidronate was administered monthly for two months. In the third week of the last administration Tc-99m-MDP bone scintigraphy was performed again, but despite sustained bone involvement, pathologic hepatic uptake was not seen on the scan. We thought that pathologic hepatic Tc-99m-MDP accumulation, may be related to the formation and aggregation of calcium oxalate and phosphate crystals which improved with pamidromat treatment.

C1 Inonu Univ, Dept Nucl Med, Turgat Ozal Med Ctr, Malatya, Turkey.

Inonu Univ, Dept Thorac Surg, Turgat Ozal Med Ctr, Malatya, Turkey.

Inonu Univ, Dept Endocrinol, Turgat Ozal Med Ctr, Malatya, Turkey.

Inonu Univ, Dept Orthoped & Traumatol, Turgat Ozal Med Ctr, Malatya, Turkey.