The effect of sevoflurane anesthesia on the corneal endothel

Abstract

Aim: To evaluate the mean changes in corneal endothelial cells in eyes that operated under sevoflurane general anesthesia. Material and Methods: 32 eyes of 32 patients who had extraocular surgery under general anesthesia included in this prospective study. Cell density (CD), Coefficient of Variation (CV) and Hexagonality rate (Hex) specular microscopy results at before surgery and 1 week and 1 month after surgery were analyzed. Results: The mean age of the patients was 15 ± 10 (min 4- max 36). The mean operation time of the patients was 90 ± 15 minutes. The mean preoperative CD value of the study subjects was 3097±15 cell/mm2. The mean postoperative CD value was 3119±194 cell/mm2 at the 1.week and 3120±207 cell/mm2 at the 1.month (p=0.678). The mean preoperative CV was 0.27±0.4 while the postoperative 1. week value was 0.27±0.4, and the postoperative 1st month value was 0.27±0.5 (p=0.319). The mean preoperative Hex value of the study subjects was 53±10%. The mean postoperative Hex value was 54±11% at the 1.week and 55±10% at the 1.month (p=0.992). No significant difference was present between the periods in terms of CD, CV and Hex. Conclusion: There is no change in the corneal endothel in patients who suffered general anesthesia with sevoflurane. Keywords: General Anesthesia; Corneal Endothel; Sevoflurane.