dc.contributor.author |
Hasçalık, Şeyma |
|
dc.contributor.author |
Çelik, Önder |
|
dc.contributor.author |
Saraç, Kaya |
|
dc.contributor.author |
Alkan, Alpay |
|
dc.contributor.author |
Mızrak, Bülent |
|
dc.date.accessioned |
2020-06-02T10:37:18Z |
|
dc.date.available |
2020-06-02T10:37:18Z |
|
dc.date.issued |
2005 |
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dc.identifier.citation |
Şeyma H., Önder Ç., Kaya S., Alpay A., Bülent M. (2005). Spectroscopy analysis of uterine leiomyomas before and after treatment with GnRH-a, GORM:Gynecology Obstetrics & Reproductive Medicine, GORM:Gynecology Obstetrics & Reproductive Medicine |
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dc.identifier.uri |
http://localhost:8080/xmlui/handle/123456789/15644 |
|
dc.description |
Öz:
Başlık (İngilizce):
Öz (İngilizce):MR spectroscopy uses the same hardware as magnetic resonance imaging but provides information at the biochemical level. It has been used to measure proton-containing compounds, such as amino acids, fatty acids, organic acids, sugars and other metabolic active compounds in tissue specimens. Before and after GnRH-a treatment we measured lipid, lactate, creatine and choline concentrations in two patients with uterine leiomyomas using single-voxel proton MR spectroscopy. Subcutaneous goserelin acetate injection was performed at least two times every 4 weeks before surgery. Spectroscopy was performed 3 weeks later last goserelin acetate injection. The MR spectroscopy results of leiomyomas before and after GnRH-a treatment were compared. Before GnRH-a treatment, spectral analysis of each patients showed only choline signals. After GnRH-a treatment, spectrum of both patients showed lipid peaks but the other signals were not observed. The presence of lipid signals and absence of other signals suggest a diffuse metabolic defect in association with GnRHa treatment, possibly consistent with decrease in myoflaments, and increase in apopitosis and necrosis. |
tr_TR |
dc.description.abstract |
Öz:
Başlık (İngilizce):
Öz (İngilizce):MR spectroscopy uses the same hardware as magnetic resonance imaging but provides information at the biochemical level. It has been used to measure proton-containing compounds, such as amino acids, fatty acids, organic acids, sugars and other metabolic active compounds in tissue specimens. Before and after GnRH-a treatment we measured lipid, lactate, creatine and choline concentrations in two patients with uterine leiomyomas using single-voxel proton MR spectroscopy. Subcutaneous goserelin acetate injection was performed at least two times every 4 weeks before surgery. Spectroscopy was performed 3 weeks later last goserelin acetate injection. The MR spectroscopy results of leiomyomas before and after GnRH-a treatment were compared. Before GnRH-a treatment, spectral analysis of each patients showed only choline signals. After GnRH-a treatment, spectrum of both patients showed lipid peaks but the other signals were not observed. The presence of lipid signals and absence of other signals suggest a diffuse metabolic defect in association with GnRHa treatment, possibly consistent with decrease in myoflaments, and increase in apopitosis and necrosis. |
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dc.language.iso |
tr |
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dc.publisher |
GORM:Gynecology Obstetrics & Reproductive Medicine |
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dc.subject |
Kadın Hastalıkları ve Doğum |
tr_TR |
dc.title |
Spectroscopy analysis of uterine leiomyomas before and after treatment with GnRH-a |
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dc.type |
Article |
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