Abstract:
Aim: High permeability in peritoneal dialysis (PD) is reported to be associated with increased mortality. Cardiovascular disease is
the most important cause of morbidity and mortality in patients with end-stage renal disease. The inflammation is thought to take
part in development of atherosclerosis. The aim of this study is to investigate the relation of peritoneal permeability type with carotid
intima media thickness (CIMT) in PD patients.
Material and Methods: Based on the standard peritoneal equilibration test, 56 PD patients (28 male) were divided in two transporter
groups: low (low+low average) and high (high+high average) permeability. C-reactive protein (CRP) measured as a marker of
inflammation and CIMT was evaluated by high-resolution B-mode ultrasonography.
Results: Twenty one patients were low and 35 of them were high peritoneal transporters. Mean CRP level was significantly higher in
the high permeability group (HPG) (1.62±1.7 vs 0.84±1 mg/dL; p=0.006). CIMT was higher in the HPG but this difference did not reach
statistical significance (0.810±0.160 vs 0.740±0.160 mm; p=0.16).
Conclusions: CRP, an indicator of inflammation, was found to be higher in the HPG. CIMT also was found to be higher in HPG
although it was not statistically significant. One of the causes of increased mortality rate in this group of patients may be explained
by inflammation and atherosclerosis.
