Abstract:
Aim: The aim of this study was to determine the correlation of corneal endothelial cell density, coefficient of variation and hexagonal
cell ratio with the stages of keratoconus and corneal thickness.
Material and Methods: The study included 102 eyes from 51 patients. The corneal topography was performed using the Sirius
corneal topographic device and the examination of the endothelium was performed using Nidek CEM-530. The patients were divided
into groups in accordance with keratometry values (group 1: K2<45 D, group 2: K2 45-52 D, group 3: K2> 52 D) and thinnest cornea
thickness (group 1:> 450 µm, group 2: 400-450 µm, group 3: <400 µm). Specular microscopic findings were compared according to
the severity of keratoconus and corneal thickness.
Results: Of the patients, 29 (50%) were male and 22 (50%) were female. The mean age was 29.8 ± 7.7 (15-45) years. Endothelial cell
count and hexagonal cell ratio were significantly lower in severe keratoconus compared to mild and moderate keratoconus and the
coefficient of variation was higher in severe keratoconus compared to the other groups (p <0.001). When the patients were compared
according to the pachymetry value at the thinnest point of the cornea, the endothelial cell number and the hexagonal cell ratio were
found to be lower in the group with pachymetry less than 400 µm (p <0.001). The coefficient of variation was higher in the same
group compared to the others (p <0.001).
Conclusion: It was revealed that endothelial cell density, hexagonal cell ratio decreased and the coefficient of variation increased
with the progression of keratoconus. Specular microscopic examinations in patients with keratoconus provide important data in
addition to topography
