Purpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases.
Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS).
Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS.
Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options.
C1 [Inal, Ali] Mersin Hosp, Dept Med Oncol, Mersin, Turkey.
[Sezer, Emel] Mersin Univ, Dept Med Oncol, Mersin, Turkey.
[Kodaz, Hilmi; Hacibekiroglu, Ilhan] Trakya Univ, Dept Med Oncol, Edirne, Turkey.
[Odabas, Hatice; Aydin, Kubra] Dr Lutfi Kirdar Kartal Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey.
[Tastekin, Didem] Istanbul Univ, Dept Med Oncol, Istanbul, Turkey.
[Cihan, Sener] Istanbul Univ, Okmeydani Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey.
[Gumus, Mahmut] Bezmialem Vakif Univ, Dept Med Oncol, Istanbul, Turkey.
[Ustaalioglu, Bala Basak Oven] Haydarpasa Numune Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey.
[Cokmert, Suna] Kent Hosp, Dept Med Oncol, Istanbul, Turkey.
[Duran, Ayse Ocak] Erciyes Univ, Dept Med Oncol, Kayseri, Turkey.
[Inanc, Mevlide] Kayseri Numune Educ & Res Hosp, Dept Med Oncol, Kayseri, Turkey.
[Seker, Mehmet Metin] Cumhuriyet Univ, Dept Med Oncol, Sivas, Turkey.
[Elkiran, Emin Tamer] Inonu Univ, Dept Med Oncol, Malatya, Turkey.
[Gunaydin, Yusuf] Gazi Univ, Dept Med Oncol, Ankara, Turkey.
[Uncu, Dogan] Ankara Numune Training & Res Hosp, Dept Med Oncol, Manisa, Turkey.
[Bal, Oznur] Ankara Onkol Educ & Res Hosp, Dept Med Oncol, Manisa, Turkey.
[Menekse, Serkan] Celal Bayar Univ, Dept Med Oncol, Manisa, Turkey.
[Topcu, Turkan Ozturk] Karadeniz Tech Univ, Dept Med Oncol, Trabzon, Turkey.
[Urakci, Zuhat; Isikdogan, Abdurrahman] Dicle Univ, Dept Med Oncol, Diyarbakir, Turkey.
[Bilici, Mehmet] Ataturk Univ, Dept Med Oncol, Erzurum, Turkey.
[Geredeli, Caglayan] Konya Numune Hosp, Dept Med Oncol, Konya, Turkey.
[Arpaci, Erkan] Sakarya Univ, Dept Med Oncol, Sakarya, Turkey.
[Ozturk, Banu] Gaziosmanpasa Univ, Dept Med Oncol, Yozgat, Turkey.
[Uysal, Mukremin] Afyon Kocatepe Univ, Dept Med Oncol, Afyon, Turkey.
[Tanriverdi, Ozgur] Mugla Sitki Kocman Univ, Dept Med Oncol, Mugla, Turkey.
[Suner, Ali] Gaziantep Univ, Dept Med Oncol, Gaziantep, Turkey.