The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t)ide analogs after liver transplantation.
C1 [Akarsu, Mesut; Onem, Soner] Dokuz Eylul Univ, Sch Med, Dept Gastroenterol, Izmir, Turkey.
[Turan, Ilker; Danis, Nilay; Karasu, Zeki] Ege Univ, Sch Med, Dept Gastroenterol, Izmir, Turkey.
[Adali, Gupse] Univ Hlth Sci, Umraniye Training & Res Hosp, Dept Gastroenterol, Istanbul, Turkey.
[Akdogan, Meral] Univ Hlth Sci, Ankara City Hosp, Dept Gastroenterol, Ankara, Turkey.
[Akyildiz, Murat; Gencdal, Genco] Koc Univ, Dept Gastroenterol, Sch Med, Istanbul, Turkey.
[Aladag, Murat] Turgut Ozal Univ, Dept Gastroenterol, Sch Med, Malatya, Turkey.
[Balaban, Yasemin] Hacettepe Univ, Dept Gastroenterol, Sch Med, Ankara, Turkey.
[Dayangac, Murat] Medipol Univ Hosp, Ctr Organ Transplantat, Istanbul, Turkey.
[Gokcan, Hale; Sertesen, Elif; Gurakar, Merve; Idilman, Ramazan] Ankara Univ, Dept Gastroenterol, Sch Med, Ankara, Turkey.
[Harputluoglu, Murat] Inonu Univ, Liver Transplantat Inst, Dept Gastroenterol, Sch Med, Malatya, Turkey.
[Kabacam, Gokhan; Karademir, Sedat] Guven Hosp, Dept Gastroenterol, Ankara, Turkey.
[Kiyici, Murat] Uludag Univ, Dept Gastroenterol, Sch Med, Bursa, Turkey.