Purpose
Soft tissue sarcomas are associated with a poor prognosis and low chemotherapeutic efficiency. Pazopanib is an orally available multi-tyrosine kinase inhibitor that was explored in patients with non-adipocytic advanced soft tissue sarcomas. The aim of this retrospective study was to evaluate the real life data of single-agent pazopanib efficacy and safety for soft tissue sarcomas in the Turkish population.
Materials and methods
We evaluated a total of 103 patients (41 males, 62 females) who received pazopanib for advanced non-adipocytic soft tissue sarcomas diagnosis in eight centers of Turkey, retrospectively. The pazopanib dose was 800 mg once daily. Progression-free survival, overall survival, and adverse events were analyzed.
Results
The median age was 50 years (range, 38-58). Majority of the patients had leimyosarcoma (41%). Median progression-free survival was 4.3 months, and the median overall survival was 10.1 months. The main common toxicities were fatigue, anorexia, weight loss, nausea, hypertension, and grade >= 3 toxicities were fatigue, anorexia, weight loss, and liver disorder.
Conclusion
Pazopanib is an efficient and tolerable agent and is well tolerated in good performance status patients with relapsed, advanced non-adipocytic soft tissue sarcomas.
C1 [Koca, Sinan] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey.
[Besiroglu, Mehmet; Dane, Faysal] Marmara Univ, Pendik Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey.
[Ozcelik, Melike] Univ Hlth Sci, Istanbul Umraniye Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey.
[Karaca, Mustafa] Gazi Univ, Dept Med Oncol, Ankara, Turkey.
[Bilici, Mehmet] Ataturk Univ, Dept Med Oncol, Erzurum, Turkey.
[Hacioglu, Bekir] Trakya Univ, Dept Med Oncol, Edirne, Turkey.
[Dogu, Gamze G.] Pamukkale Univ, Dept Med Oncol, Denizli, Turkey.
[Kaplan, Nihal B.] Inonu Univ, Dept Med Oncol, Malatya, Turkey.
[Oruc, Zeynep] Dicle Univ, Dept Med Oncol, Diyarbakir, Turkey.
[Aydin, Dincer] Dr Lutfi Kirdar Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey.