dc.contributor.author |
Koca, S |
|
dc.contributor.author |
Besiroglu, M |
|
dc.contributor.author |
Ozcelik, M |
|
dc.contributor.author |
Karaca, M |
|
dc.contributor.author |
Bilici, M |
|
dc.contributor.author |
Hacioglu, B |
|
dc.contributor.author |
Dogu, GG |
|
dc.contributor.author |
Kaplan, NB |
|
dc.contributor.author |
Oruc, Z |
|
dc.contributor.author |
Aydin, D |
|
dc.contributor.author |
Dane, F |
|
dc.date.accessioned |
2022-10-05T13:18:08Z |
|
dc.date.available |
2022-10-05T13:18:08Z |
|
dc.date.issued |
2021 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/62646 |
|
dc.description.abstract |
Purpose |
|
dc.description.abstract |
Soft tissue sarcomas are associated with a poor prognosis and low chemotherapeutic efficiency. Pazopanib is an orally available multi-tyrosine kinase inhibitor that was explored in patients with non-adipocytic advanced soft tissue sarcomas. The aim of this retrospective study was to evaluate the real life data of single-agent pazopanib efficacy and safety for soft tissue sarcomas in the Turkish population. |
|
dc.description.abstract |
Materials and methods |
|
dc.description.abstract |
We evaluated a total of 103 patients (41 males, 62 females) who received pazopanib for advanced non-adipocytic soft tissue sarcomas diagnosis in eight centers of Turkey, retrospectively. The pazopanib dose was 800 mg once daily. Progression-free survival, overall survival, and adverse events were analyzed. |
|
dc.description.abstract |
Results |
|
dc.description.abstract |
The median age was 50 years (range, 38-58). Majority of the patients had leimyosarcoma (41%). Median progression-free survival was 4.3 months, and the median overall survival was 10.1 months. The main common toxicities were fatigue, anorexia, weight loss, nausea, hypertension, and grade >= 3 toxicities were fatigue, anorexia, weight loss, and liver disorder. |
|
dc.description.abstract |
Conclusion |
|
dc.description.abstract |
Pazopanib is an efficient and tolerable agent and is well tolerated in good performance status patients with relapsed, advanced non-adipocytic soft tissue sarcomas. |
|
dc.description.abstract |
C1 [Koca, Sinan] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey. |
|
dc.description.abstract |
[Besiroglu, Mehmet; Dane, Faysal] Marmara Univ, Pendik Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey. |
|
dc.description.abstract |
[Ozcelik, Melike] Univ Hlth Sci, Istanbul Umraniye Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey. |
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dc.description.abstract |
[Karaca, Mustafa] Gazi Univ, Dept Med Oncol, Ankara, Turkey. |
|
dc.description.abstract |
[Bilici, Mehmet] Ataturk Univ, Dept Med Oncol, Erzurum, Turkey. |
|
dc.description.abstract |
[Hacioglu, Bekir] Trakya Univ, Dept Med Oncol, Edirne, Turkey. |
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dc.description.abstract |
[Dogu, Gamze G.] Pamukkale Univ, Dept Med Oncol, Denizli, Turkey. |
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dc.description.abstract |
[Kaplan, Nihal B.] Inonu Univ, Dept Med Oncol, Malatya, Turkey. |
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dc.description.abstract |
[Oruc, Zeynep] Dicle Univ, Dept Med Oncol, Diyarbakir, Turkey. |
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dc.description.abstract |
[Aydin, Dincer] Dr Lutfi Kirdar Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey. |
|
dc.source |
JOURNAL OF ONCOLOGY PHARMACY PRACTICE |
|
dc.title |
Pazopanib for metastatic soft-tissue sarcoma: A multicenter |
|
dc.title |
retrospective study |
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