In our study, we aimed to evaluate the pathological response rates and side effect profile of adding pertuzumab to the treatment of HER2+ locally advanced, inflammatory, or early-stage breast cancer. This study was conducted by the Turkish Oncology Group (TOG) with data collected from 32 centers. Our study was multicentric, and a total of 364 patients were included. The median age of the patients was 49 years (18-85 years). Two hundred fifteen (60%) of the cases were hormone receptor/HER2+ positive(ER+ or PR+, or both), and 149 (40%) of them were HER2-rich (ER and PR negative). The number of complete responses was 124 (54%) in the docetaxel+trastuzumab+pertuzumab arm and 102 (45%) in the paclitaxel+trastuzumab+pertuzumab arm, and there was no difference between the groups in terms of complete response. In 226 (62%) patients with complete response, a significant correlation was found with DCIS, tumor focality, removed lymph node, and ER status P < 0.05. Anemia, nausea, vomiting, myalgia, alopecia, and mucosal inflammation were significantly higher in the docetaxel arm, P < 0.05. In our study, no statistical difference was found between the before-after echocardiography values. DCIS positivity in biopsy before neoadjuvant chemotherapy, tumor focality; the number of lymph nodes removed and ER status were found to be associated with pCR. In conclusion, we think that studies evaluating pCR-related clinicopathological variables and radiological imaging features will play a critical role in the development of nonsurgical treatment approaches.
C1 [Ozdemir, Ozlem; Yildiz, Yasar; Yilmaz, Cengiz; Alacacioglu, Ahmet] Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Med Oncol, Izmir, Turkey.
[Zengel, Baha] Katip Celebi Univ, Ataturk Training & Res Hosp, Bozyaka Training & Res Hosp, Dept Gen Surg, Izmir, Turkey.
[Uluc, Basak Oyan; Demir, Atakan; Sonmez, Ozlem Uysal] Acibadem Hosp, Dept Med Oncol, Istanbul, Turkey.
[Cabuk, Devrim; Ozden, Ercan] Kocaeli Univ, Dept Med Oncol, Fac Med Hosp, Kocaeli, Turkey.
[Salim, Derya Kivrak] Hlth Sci Univ, Dept Med Oncol, Antalya Training & Res Hosp, Antalya, Turkey.
[Paydas, Semra] Cukurova Univ, Dept Med Oncol, Fac Med, Adana, Turkey.
[Diker, Omer] Near East Univ Hosp, Dept Med Oncol, Nicosia, Cyprus.
[Pilanci, Kezban Nur] Mem Bahcelievler Hosp, Dept Med Oncol, Istanbul, Turkey.
[Vatansever, Sezai; Dogan, Izzet] Istanbul Univ, Dept Med Oncol, Fac Med, Istanbul, Turkey.
[Gulmez, Ahmet] Inonu Univ, Dept Med Oncol, Fac Med, Malatya, Turkey.
[Cakar, Burcu; Gursoy, Pinar] Ege Univ, Dept Med Oncol, Fac Med, Izmir, Turkey.
[Yildirim, Mahmut Emre; Ayhan, Murat] Kartal Dr Lutfi Kirdar City Hosp, Dept Med Oncol, Istanbul, Turkey.
[Karadurmus, Nuri; Aykan, Musa Baris] Hlth Sci Univ, Dept Med Oncol, Gulhane Training & Res Hosp, Ankara, Turkey.
[Cevik, Gokcen Tugba] Usak Univ, Dept Med Oncol, Training & Res Hosp, Usak, Turkey.
[Sakalar, Teoman] Kahramanmaras Necip Fazil City Hosp, Dept Med Oncol, Kahramanmaras, Turkey.
[Hacibekiroglu, Ilhan; Gulbagci, Burcu Belen] Sakarya Univ, Dept Med Oncol, Training & Res Hosp, Sakarya, Turkey.
[Dincer, Murat; Garbioglu, Duygu Bayir] Osmangazi Univ, Dept Med Oncol, Fac Med Hosp, Eskisehir, Turkey.
[Kemal, Yasemin] Med Pk Hosp, Dept Med Oncol, Samsun, Turkey.
[Nayir, Erdinc] Med Pk Hosp, Dept Med Oncol, Mersin, Turkey.
[Taskaynatan, Halil] Private Ege City Hosp, Dept Med Oncol, Izmir, Turkey.
[Yilmaz, Mesut] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey.
[Avci, Okan] Namik Kemal Univ Hosp, Dept Med Oncol, Tekirdag, Turkey.
[Sari, Murat; Coban, Ezgi] Haydarpasa Numune Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey.
[Atci, Muhammed Mustafa] Prof Dr Cemil Tascioglu City Hosp, Dept Med Oncol, Istanbul, Turkey.
[Esen, Selin Akturk] Ankara City Hosp, Dept Med Oncol, Ankara, Turkey.
[Telli, Tugba Akin] Marmara Univ, Dept Med Oncol, Fac Med, Istanbul, Turkey.
[Karatas, Fatih] Karabuk Univ, Dept Med Oncol, Fac Med, Karabuk, Turkey.
[Inal, Ali] Mersin City Training & Res Hosp, Dept Med Oncol, Mersin, Turkey.
[Demir, Hacer] Afyonkarahisar Hlth Sci Univ, Dept Med Oncol, Afyon, Turkey.
[Kalkan, Nurhan Onal] Van Yuzuncu Yil Fac Med, Dept Med Oncol, Van, Turkey.
[Tasli, Funda] Bozyaka Training & Res Hosp, Dept Pathol, Izmir, Turkey.