The effectiveness and safety of neoadjuvant pertuzumab and trastuzumab

Abstract

In our study, we aimed to evaluate the pathological response rates and side effect profile of adding pertuzumab to the treatment of HER2+ locally advanced, inflammatory, or early-stage breast cancer. This study was conducted by the Turkish Oncology Group (TOG) with data collected from 32 centers. Our study was multicentric, and a total of 364 patients were included. The median age of the patients was 49 years (18-85 years). Two hundred fifteen (60%) of the cases were hormone receptor/HER2+ positive(ER+ or PR+, or both), and 149 (40%) of them were HER2-rich (ER and PR negative). The number of complete responses was 124 (54%) in the docetaxel+trastuzumab+pertuzumab arm and 102 (45%) in the paclitaxel+trastuzumab+pertuzumab arm, and there was no difference between the groups in terms of complete response. In 226 (62%) patients with complete response, a significant correlation was found with DCIS, tumor focality, removed lymph node, and ER status P < 0.05. Anemia, nausea, vomiting, myalgia, alopecia, and mucosal inflammation were significantly higher in the docetaxel arm, P < 0.05. In our study, no statistical difference was found between the before-after echocardiography values. DCIS positivity in biopsy before neoadjuvant chemotherapy, tumor focality; the number of lymph nodes removed and ER status were found to be associated with pCR. In conclusion, we think that studies evaluating pCR-related clinicopathological variables and radiological imaging features will play a critical role in the development of nonsurgical treatment approaches.

C1 [Ozdemir, Ozlem; Yildiz, Yasar; Yilmaz, Cengiz; Alacacioglu, Ahmet] Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Med Oncol, Izmir, Turkey.

[Zengel, Baha] Katip Celebi Univ, Ataturk Training & Res Hosp, Bozyaka Training & Res Hosp, Dept Gen Surg, Izmir, Turkey.

[Uluc, Basak Oyan; Demir, Atakan; Sonmez, Ozlem Uysal] Acibadem Hosp, Dept Med Oncol, Istanbul, Turkey.

[Cabuk, Devrim; Ozden, Ercan] Kocaeli Univ, Dept Med Oncol, Fac Med Hosp, Kocaeli, Turkey.

[Salim, Derya Kivrak] Hlth Sci Univ, Dept Med Oncol, Antalya Training & Res Hosp, Antalya, Turkey.

[Paydas, Semra] Cukurova Univ, Dept Med Oncol, Fac Med, Adana, Turkey.

[Diker, Omer] Near East Univ Hosp, Dept Med Oncol, Nicosia, Cyprus.

[Pilanci, Kezban Nur] Mem Bahcelievler Hosp, Dept Med Oncol, Istanbul, Turkey.

[Vatansever, Sezai; Dogan, Izzet] Istanbul Univ, Dept Med Oncol, Fac Med, Istanbul, Turkey.

[Gulmez, Ahmet] Inonu Univ, Dept Med Oncol, Fac Med, Malatya, Turkey.

[Cakar, Burcu; Gursoy, Pinar] Ege Univ, Dept Med Oncol, Fac Med, Izmir, Turkey.

[Yildirim, Mahmut Emre; Ayhan, Murat] Kartal Dr Lutfi Kirdar City Hosp, Dept Med Oncol, Istanbul, Turkey.

[Karadurmus, Nuri; Aykan, Musa Baris] Hlth Sci Univ, Dept Med Oncol, Gulhane Training & Res Hosp, Ankara, Turkey.

[Cevik, Gokcen Tugba] Usak Univ, Dept Med Oncol, Training & Res Hosp, Usak, Turkey.

[Sakalar, Teoman] Kahramanmaras Necip Fazil City Hosp, Dept Med Oncol, Kahramanmaras, Turkey.

[Hacibekiroglu, Ilhan; Gulbagci, Burcu Belen] Sakarya Univ, Dept Med Oncol, Training & Res Hosp, Sakarya, Turkey.

[Dincer, Murat; Garbioglu, Duygu Bayir] Osmangazi Univ, Dept Med Oncol, Fac Med Hosp, Eskisehir, Turkey.

[Kemal, Yasemin] Med Pk Hosp, Dept Med Oncol, Samsun, Turkey.

[Nayir, Erdinc] Med Pk Hosp, Dept Med Oncol, Mersin, Turkey.

[Taskaynatan, Halil] Private Ege City Hosp, Dept Med Oncol, Izmir, Turkey.

[Yilmaz, Mesut] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey.

[Avci, Okan] Namik Kemal Univ Hosp, Dept Med Oncol, Tekirdag, Turkey.

[Sari, Murat; Coban, Ezgi] Haydarpasa Numune Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey.

[Atci, Muhammed Mustafa] Prof Dr Cemil Tascioglu City Hosp, Dept Med Oncol, Istanbul, Turkey.

[Esen, Selin Akturk] Ankara City Hosp, Dept Med Oncol, Ankara, Turkey.

[Telli, Tugba Akin] Marmara Univ, Dept Med Oncol, Fac Med, Istanbul, Turkey.

[Karatas, Fatih] Karabuk Univ, Dept Med Oncol, Fac Med, Karabuk, Turkey.

[Inal, Ali] Mersin City Training & Res Hosp, Dept Med Oncol, Mersin, Turkey.

[Demir, Hacer] Afyonkarahisar Hlth Sci Univ, Dept Med Oncol, Afyon, Turkey.

[Kalkan, Nurhan Onal] Van Yuzuncu Yil Fac Med, Dept Med Oncol, Van, Turkey.

[Tasli, Funda] Bozyaka Training & Res Hosp, Dept Pathol, Izmir, Turkey.