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Purpose: This study investigated the effects of health belief model-based education and acupressure for coping with premenstrual syndrome (PMS) on premenstrual symptoms and quality of life. Design and Methods: The sample size was identified as 163 women. While the acupressure education group-administered education and acupressure, the education group-administered only education. No intervention made to the control group. Findings: There was a significant difference between the pretest and posttest total mean scores of the intervention groups compared with the control group (P <.001). Practice Implications: The education given to women for coping with PMS and acupressure both reduced premenstrual symptoms and improved quality of life. © 2020 Wiley Periodicals LLC