Trends of primary glomerular disease in Turkey: TSN-GOLD registry report
Gül, C.B.; Küçük, M.; Öztürk, S.; Demir, E.; Eren, N.; Şumnu, A.; Seyahi, N.; Güllülü, M.; Dede, F.; Derici, Ü.; Koç, Y.; Şahin, G.; Oymak, O.; Sahin, G.M.; Tatar, E.; Dursun, B.; Dheir, H.; Apaydın, S.; Süleymanlar, G.; Ulu, S.; Altınören, O.; Kutlay, S.; Meşe, M.; Şahin, İ.; Üstündağ, S.; Türkmen, K.; Yılmaz, M.E.; Kazancıoğlu, R.T.; Uzun, Ö.; Candan, F.; Aydın, Z.; Oygar, D.; Aktaş, N.; Erdem, Y.; Paydaş, S.; Taymez, D.; Can, B.; Kıykım, A.; Koç, L.; Sezer, S.; Duranay, M.; Bardak, S.; Altıntepe, L.; Kaya, B.; Azak, A.; Ecder, S.A.; Çavdar, C.; Selçuk, N.Y.
Date:
2022
Abstract:
Background: Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. Methods: Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013–2017, and 2017–current. Results: A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (× 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (× 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. Conclusions: In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.
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