Abstract:
Objective: To investigate the prognostic factors of patients with Grade 3 endometrioid endometrial cancer (G3EEC). Methods: This four-center, retrospective study included a total of 129 women with G3EEC. Demographic, clinicopathologic, and survival data were collected. Kaplan–Meier method was used for survival analysis. Predictors of outcome were analyzed using Cox proportional hazards models. Results: Median age at the time of diagnosis was 63 (range 39–87) years and median follow up was 37 (range 6–126) months. For the entire cohort, the 5-year disease-free survival (DFS) and overall survival (OS) were 54.3% and 63.6%, respectively. The 5-year DFS rates for lymphovascular space invasion (LVSI) -positive and -negative patients were 41.6% and 88.3%, respectively (P < 0.001). The 5-year OS rates for LVSI-positive and -negative patients were 54.7% and 88.3%, respectively (P = 0.001). Positive LVSI status was identified as the independent prognostic factor for decreased DFS and OS (hazard ratio [HR] 5.5, 95% confidence interval [CI] 1.65–18.86; P = 0.006 versus HR 4.4, 95% CI 1.33–14.58; P = 0.013, respectively). Conclusion: LVSI seems to be an independent prognostic factor for decreased DFS and OS in G3EEC patients. © 2022 International Federation of Gynecology and Obstetrics.