Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by fever and accompanying attacks of serositis. Cytokines such as IL-6, TNF-alpha, IL-1 beta are known to play an active role in FMF pathogenesis. Gilbert's syndrome, is a clinical condition that results indirect hyperbilirubinemia during febrile illness, surgery, vomiting and prolonged fasting period because of inhibition of UDP-glucuronide transferase activity. Increased bilirubin levels during FMF attack is caused suppression of UDP-glucuronide transferase activity by cytokines involved in the pathogenesis of FMF. Here, we report a patient who had serious indirect bilirubin elevation during an attack of FMF.
C1 [Kutlu, Orkide] Okmeydani Egitim & Arastirma Hastanesi, Ic Hastaliklari Bolumu, Istanbul, Turkey.
[Keskin, Muharrem; Ecirli, Samil; Fisekci Oktar, Sevil] Konya Egitim & Arastirma Hastanesi, Ic Hastaliklari Klin, Konya, Turkey.
[Basturk, Abdulkadir] Selcuk Univ, Tip Fak, Hematol Bolumu, Konya, Turkey.
[Bilgic, Yilmaz] Inonu Univ, Turgut Ozal Tip Merkezi, Gastroenterol Bolumu, Malatya, Turkey.