Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100nm, similar to quinine.
C1 [Panda, Siva S.; Ibrahim, Mohamed A.; Kucukbay, Hasan; Katritzky, Alan R.] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA.
[Ibrahim, Mohamed A.] Misr Univ Sci & Technol, Dept Organ Chem, Coll Pharm, Al Motamayez Dist, Egypt.
[Ibrahim, Mohamed A.; El-Feky, Said A.] Zagazig Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Zagazig 44519, Egypt.
[Kucukbay, Hasan] Univ Inonu, Dept Chem, Fac Arts & Sci, TR-44280 Malatya, Turkey.
[Meyers, Marvin J.; Sverdrup, Francis M.] St Louis Univ, Ctr World Hlth & Med, St Louis, MO 63104 USA.
[Katritzky, Alan R.] King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia.