Borna disease virus (BDV) causes behavioral disorders in rats infected in the newborn period. We investigated BDV serology in children with attention deficit hyperactivity disorder (ADHD).
Method: Ninety-nine children with ADHD (mean age: 8.7 +/- 2.5) and 104 control children (mean age: 8.4 +/- 2.8) were included in the study. All sera were investigated using the Enzyme-Linked Immunosorbent Assay (ELISA) method for BDV antibodies.
Results: The rate of sero-positivity was 2% (2 of 99) in ADHD and 3.8% (4 of 104) in the control group. There was no significant difference between ADHD and control group for BDV sero-positivity.
Conclusion: Our results do not support a role of BDV infections in the pathogenesis of ADHD.
C1 [Ozcan, Ozlem] Inonu Univ, Fac Med, Dept Child Psychiat, Malatya, Turkey.
[Gungor, Serdal] Inonu Univ, Fac Med, Dept Pediat Neurol, Malatya, Turkey.
[Helps, Chris R.] Univ Bristol, Sch Clin Vet Sci, Div Vet Pathol, Bristol BS8 1TH, Avon, England.
[Turan, Nuri; Saget, Hasan; Yilmaz, Hueseyin] Istanbul Univ, Fac Vet, Dept Virol, Istanbul, Turkey.
[Tabel, Yilmaz] Inonu Univ, Fac Med, Dept Pediat, Malatya, Turkey.