Mycobacterium tuberculosis (H37Rv)-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n = 9), isoniazid (n = 5) or saline (n = 6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P > 0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P > 0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model. (C) 2003 Elsevier Ltd. All rights reserved.
C1 Univ Inonu, Sch Med, Dept Pulm Med, Turgut Ozal Med Ctr, TR-44069 Malatya, Turkey.
Univ Inonu, Sch Med, Dept Paediat, Malatya, Turkey.
Univ Inonu, Sch Med, Dept Pathol, Malatya, Turkey.
Anadolu Univ, TBAM, Eskisehir, Turkey.
Univ Inonu, Sch Med, Dept Pharmacol, Malatya, Turkey.
Univ Inonu, Sch Med, Dept Microbiol, Malatya, Turkey.