Abstract:
The subject of automatic detection of the presence of cervical cancer by evaluating histopathological Pap- Smear images with computerized diagnosis / detection software is an active field of study. The reason for this is that the objects (cell nucleus, cytoplasm, white blood cell, bacilli and speckle) in the visuals overlap and change the geometric structure and pattern of each other, they are dispersed in the image with different density, and the noise patterns are different. In addition, the difficulty and costs of creating a tagged large dataset prevented the emergence of a common dataset in this area. The mentioned difficulties negatively affect the achievements in current classification studies and trigger the need for new approaches. In this paper, a three-step approach based on building large Pap-Smear datasets using Generative Adversarial Networks (GANs) is proposed. Accordingly, in the first step, geometric shape and pattern models of each object structure in Pap-Smear images are created. In the second stage, synthetic Pap-Smear images (Ground True) with the desired number and distribution of objects are produced using the produced parametric models. In the third stage, the performances of existing GANs (Pix2Pix, CycleGAN, DiscoGAN and AttentionGAN) to produce GT are evaluated and a solution-oriented new current GAN architecture (Pix2PixSSIM) is proposed. Experimental studies show that a large Pap-Smear data set can be produced in a very short time with the proposed GAN architecture. In this way, it is seen that deep networks with high classification success can be trained. © 2022 Gazi Universitesi Muhendislik-Mimarlik. All rights reserved.